SF3B4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1275 Sequence: atggctgccg ggccgatctc cgagcggaat caggatgcca ctgtgtacgt ggggggcctg gatgagaagg ttagtgaacc gctgctgtgg gaactgtttc tccaggctgg accagtagtc aacacccaca tgccaaagga tagagtcact ggccagcacc aaggctatgg ctttgtggaa ttcttgagtg aggaagatgc tgactatgcc attaagatca tgaacatgat caaactctat gggaagccaa tacgggtgaa caaagcatca gctcacaaca aaaacctgga tgtaggggcc aacattttca ttgggaacct ggaccctgag attgatgaga agttgcttta tgatactttc agcgcctttg gggtcatctt acaaaccccc aaaattatgc gggaccctga cacaggcaac tccaaaggtt atgcctttat taattttgct tcatttgatg cttcggatgc agcaattgaa gccatgaatg ggcagtacct ctgtaaccgt cctatcaccg tatcttatgc cttcaagaag gactccaagg gtgagcgcca tggctcagca gccgaacgac ttctggcagc tcagaacccg ctctcccagg ctgatcgccc tcatcagctg tttgcagatg cacctcctcc accctctgct cccaatcctg tggtatcatc attggggtct gggcttcctc caccaggcat gcctcctcct ggctccttcc cacccccagt gccacctcct ggagccctcc cacctgggat acccccagcc atgcccccac cacctatgcc tcctggggct gcaggacatg gccccccatc ggcaggaacc ccaggggcag gacatcctgg tcatggacac tcacatcctc acccattccc accgggtggg atgccccatc cagggatgtc tcagatgcag cttgcacacc atggccctca tggcttagga catccccacg ctggaccccc aggctctggg ggccagccac cgccccgacc accacctgga atgcctcatc ctggacctcc tccaatgggc atgccccccc gagggcctcc attcggatct cccatgggtc acccaggtcc tatgcctccg catggtatgc gtggacctcc tccactgatg cccccccatg gatacactgg ccctccacga cccccaccct atggctacca gcgggggcct ctccctccac ccagacccac tccccggcca ccagttcccc ctcgaggccc acttcgaggc cctctccctc Protein function: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well (PubMed:10882114). Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron (PubMed:15146077). [The UniProt Consortium]