SETX (Vector pENTR223.1, Accession No. BC032600)

Length: 2487 Sequence: atgcgtaatg ggaaaactga gtgttacctt tccatccaga ctcaagagaa ctttccggcc aatttaaacg aacttgtgaa ttgtattgta atcagttctc tggtaactac acaaaggaag ttgaaagcca tgtctctgtt gggtagtcgg aaccaactgg ctagagctgt tctgaatcca aaccctatgg acttctgtac aaaagattta ctgactacaa catctgagag aattattgcg tacttaagag atttcaatga agatcaaaag aaagcaatag aaactgcata tgctatggtg aaacactcac catcagttgc caaaatctgc ttgattcatg gaccacctgg aacaggaaaa tcaaaaacta ttgttggcct cctctatcgt ctactgacag agaaccagag gaaggggcat tcagacgaaa actccaatgc caaaatcaaa caaaaccgtg tcctcgtgtg tgcaccttcc aatgcagctg ttgatgaact catgaaaaaa attatccttg aattcaaaga aaaatgtaaa gacaagaaga atcctttagg aaactgtgga gatataaatt tagtacgact gggtccagaa aagtctatta atagtgaggt tctaaagttc agtttggaca gccaagtaaa ccacagaatg aaaaaagagt taccttctca tgttcaggcg atgcataaaa gaaaggaatt tctagattat cagctggatg agctttcccg gcagcgagct ctatgccgag gtggacggga aatacagagg caagaattag atgaaaacat ttccaaagtt tctaaggaaa ggcaggaact tgcttctaaa attaaagagg ttcaaggacg cccacagaaa acacagagta tcatcatctt agagtcccat atcatctgct gcacgttgag cacaagtggt ggtttactac ttgagtctgc tttccgtggg caagggggtg tccccttcag ctgtgtcatt gttgatgagg ctggacagtc ttgtgaaatt gagactctta ctccactcat ccatcgctgc aataagctca tcctagtagg agatcctaag cagctccctc cgacagtcat ctctatgaaa gcacaggagt atggctacga ccagtcaatg atggctcgct tctgcagact gctggaagag aatgtagaac acaacatgat cagcaggctg cccattctac agctcactgt tcagtacagg atgcatccag acatatgcct cttcccttct aattatgttt ataacagaaa cttaaaaaca aatagacaga cagaagccat tcgatgttca tcagattggc catttcagcc ataccttgtg tttgatgttg gagatggttc agaaagacgg gataatgact catatataaa tgttcaagaa ataaaactgg tgatggaaat aattaagctt attaaagaca aaagaaagga tgttagtttt cgaaacattg gcataataac tcattacaag gcccagaaga cgatgattca gaaggatttg gacaaagagt tcgatagaaa aggaccagca gaagtagaca ctgtggatgc attccagggt cggcagaagg attgtgttat tgttacgtgt gtcagagcaa atagcatcca aggttcaatt ggattcctgg caagtttgca gagattgaat gtcaccatca cacgagccaa gtacagcctc ttcatcctcg gacatttgag gaccctgatg gaaaaccagc attggaatca gctgattcag gatgctcaga agcgtggtgc cattattaag acctgtgaca aaaactatag acatgatgca gtgaagattc tgaaactcaa gcctgtgctg cagagaagtc tcactcaccc tcctaccata gccccagagg ggtccagacc ccagggtggt ttgcccagca gcaagctaga cagtggattt gccaagacat ctgttgctgc ttctctatac cacacaccct ctgactccaa ggaaattact cttactgtta cttcaaagga ccctgaaaga cctcctgttc atgaccaact tcaggaccca cgactgctga agaggatggg cattgaggtc aaaggaggaa tattcctttg ggatccacaa ccctcgagcc cccagcatcc tggagcaaca cctcctacgg gcgagccggg cttccctgtc gttcaccagg acctgagcca tatacagcag cccgctgctg tagtggctgc tctgagcagc cacaaacctc ccgtgcgggg cgaacctcca gctgccagtc ccgaggcttc cacgtgtcag agcaaatgtg atgacccgga agaggagctc tgtcacagga gagaggccag ggctttcagt gaaggggagc aggagaagtg tggttccgag acccatcaca ccaggaggaa ctctaggtgg gacaagagga cactggagca ggaggacagc agttccaaga aaagaaagct Protein function: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G- rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation. Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription- induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111). [The UniProt Consortium]