SBF2 (Vector pUC, Accession No. BC101466)

Length: 5550 Sequence: atggcccggc tggctgacta cttcattgtg gtaggctatg accacgagaa gccaggatca ggagaaggtc tggggaaaat aatccagaga tttccacaga aggactggga tgatacacct tttccacagg gaattgagtt gttttgtcag cctggcgggt ggcagctgtc cagagagagg aagcagccaa cgttctttgt ggttgtcctg acagacattg actcagatcg acattactgc tcatgcctaa ccttctatga ggcagagatc aatcttcagg gaacaaagaa ggaagagatt gaaggtgaag caaaagtgtc tggtttaatt cagcctgcag aagtgtttgc tcccaaaagc ctggtgttgg tatccagatt atattatcca gaaattttta gggcttgcct gggtttgatc tataccgtgt atgtggacag cctgaatgtc tccttggaaa gtctaattgc aaacctttgt gcctgccttg tcccagcggc tggagggtct cagaagctgt tttctttggg tgcaggagat agacagttga tccagactcc tttacatgat agtcttccta tcacgggcac tagtgtggct ctcctgttcc agcaattggg aattcaaaat gtcctcagcc tcttttgtgc agtcctcaca gaaaataagg ttctcttcca ttctgcaagt ttccagagac ttagtgatgc ttgtagagcc ctggaatctt taatgtttcc tcttaaatat agttatcctt atatccctat tctcccggct cagctactgg aagttctaag ttccccaacg cctttcatta ttggagtaca ttctgtcttt aaaactgatg tccatgaact tttagatgta atcatagcag atttggatgg aggcactatt aaaattcccg aatgtattca cctctcttcc ctcccagaac cacttctaca tcagactcaa tcagctcttt ctttgatttt acacccagat ttggaagtag cagatcatgc ttttcctcct ccacgaacag ctttatccca ctcaaaaatg ctggataaag aggtgcgagc cgttttcctt agattatttg cacaactctt ccaaggatat agatcctgcc tgcaacttat aagaattcat gcagagccag taatacattt ccacaagaca gcattcttgg ggcagcgtgg tttggtcgag aatgatttcc tcactaaagt actcagtgga atggcatttg caggttttgt ttcagaaaga ggtcctcctt atagatcttg tgatctcttt gatgagttgg tagcctttga agtagagaga attaaagttg aagaaaataa cccagtgaag atgataaagc atgtcaggga acttgctgag caactattca aaaatgagaa tccaaatcct catatggcat tccagaaagt tccacggcca acagaaggat cccatttgcg agttcatatt cttcctttcc cagagattaa tgaagcccgg gttcaggaat taatacagga aaatgttgct aagaaccaga atgcacctcc tgccacacga atagaaaaga aatgtgttgt gccagcaggt ccacctgttg tttcgataat ggacaaggtg acgacagttt tcaacagtgc acaaagacta gaagttgtca gaaactgtat ctcattcata tttgaaaata aaattttgga aactgaaaag acccttcctg ctgcactcag agcccttaaa ggaaaggcag caagacagtg tctcactgat gaattgggtt tgcatgtcca gcaaaaccgg gcaatattag accatcaaca gtttgactac ataataagga tgatgaattg tactctacag gattgttcaa gtttagaaga atacaacatt gccgcagcat tactcccttt gaccagtgct ttctatagga aacttgcccc tggagtcagc cagtttgctt acacgtgtgt acaagaccac cccatttgga caaatcagca attttgggag acaacctttt acaatgcagt gcaggaacag gttcgctccc tttatctctc agccaaggaa gacaatcatg ccccgcatct gaagcaaaag gataagcttc ctgatgacca ttatcaggag aagacagcaa tggacctggc agctgagcaa ctacgccttt ggcctaccct gagcaagtca actcagcaag agctagtgca acatgaggaa agcactgtct ttagtcaggc cattcacttt gcaaacctca tggtgaacct gctagttcca ctcgacacaa gtaaaaacaa gctcctaaga acatcagcgc caggtgactg ggagagcgga agcaacagca ttgtcacaaa cagtattgca ggaagtgtag ctgagagcta tgatacagag agtgggtttg aagattcaga gaatactgac attgccaatt ctgttgtgcg gttcattacc cgatttattg acaaagtttg tacagagagt ggagttactc aggatcacat caagagcctt cattgcatga taccaggaat tgtagctatg cacattgaga ccctagaagc agtacatcga gaaagcagaa gacttccgcc tattcagaag cccaagattc ttagacctgc tctgctgcca ggagaagaaa ttgtctgtga gggtcttcga gtcttgctgg atcctgatgg aagagaagaa gctactggag gtcttcttgg aggccctcag ctcctgccag cagaaggagc cttgttcctc accacataca gaattctctt cagaggaaca ccccatgatc agttagtggg tgagcagaca gttgtgcgga gctttcccat tgcctccatc accaaggaga agaagattac aatgcagaac cagctacagc agaacatgca agaaggactg cagatcacat cagcatcttt tcagttgatt aaggtagcat ttgatgaaga agtcagtcca gaagtagtag agatctttaa gaaacagctg atgaagttcc gttatcctca gtccattttc agtacctttg cttttgctgc tggacaaact accccacaaa taattttacc aaaacagaag gaaaagaaca cttcttttcg taccttctca aaaacaattg tgaaaggtgc caaaagggca gggaaaatga caattgggcg gcaatattta ctgaagaaga agacagggac aattgtggaa gaaagagtaa atcgtcctgg atggaatgaa gatgatgatg tatctgtttc agatgagagt gagctcccca caagtaccac cctgaaggcc tccgagaagt ctacaatgga acagttggtg gaaaaagctt gtttcagaga ctatcagcgt ttaggtttag gaaccataag tggcagctct tcccgttcaa gacccgagta ttttagaatt actgcctcca acaggatgta ttcactctgc cggagctatc ctggcctttt agtcgtacct caagctgtac aggacagtag tttaccaaga gtagctcgct gctatcgaca caatcgcctg cctgttgtat gttggaagaa ctcaagaagt ggtactctgc tcctccgatc tggaggattc catgggaagg gagtcgttgg tcttttcaaa tctcagaact cccctgaggc cgctcctacc tcctctttag aatcttccag tagcatagaa caagagaaat acttgcaagc cttactgaat gctgtttctg tccatcagaa actcagaggc aacagcactc ttactgtcag gccagccttt gctctatctc caggtgtgtg ggcaagtctt cgctctagca ctcgcttgat cagctctcca acatccttca ttgatgttgg cgcccggctg gcaggcaagg atcactcggc ctccttcagt aacagcagct acctacaaaa ccagctcttg aaacggcaag cagcccttta catatttggt gaaaagtcgc aactaaggaa cttcaaggta gaatttgctt taaattgtga gtttgttcct gttgaatttc atgaaatccg gcaagtgaaa gccagtttta agaagctgat gagggcttgt atcccaagca ccatccctac tgactcagaa gtgaccttcc tgaaagcgct gggagattct gagtggttcc cacagcttca caggataatg cagctggctg tggttgtatc agaagtactt gagaatggtt cctcagtttt ggtctgtttg gaggaaggct gggacatcac tgcacaagtg acatccctgg ttcagttact cagtgatccc ttttatagga cacttgaagg cttccagatg ttggttgaaa aagagtggct ctcttttggt cacaaattca gtcagaggag cagcttgacc ctcaactgtc aggggagtgg ttttgctcca gtcttcttac agttcttaga ctgtgtacac caggttcaca accagtatcc aactgagttt gaattcaatc tctattactt aaagttcttg gctttccact atgtgtctaa tcgctttaaa acatttctcc tggattcaga ctatgaaaga ttagagcacg gaactttatt tgatgataaa ggagaaaagc atgccaaaaa aggagtctgt atttgggaat gtattgacag aatgcacaag aggagtccca ttttctttaa ttatttatat tcaccattgg aaatagaggc tctaaagccc aatgtaaacg tctctagcct caagaagtgg gattactaca tagaagagac cctgtccaca ggcccttcct atgactggat gatgctaacc cccaagcact tcccctccga agactctgac ctggctggag aagctgggcc acggagccag aggagaacag tgtggccatg ctatgatgat gtcagctgta ctcagcctga tgctctcacc agccttttca gtgaaattga aaaattggag cacaaattga accaagcccc tgagaagtgg cagcagctgt gggaaagggt aaccgtggac cttaaagaag aaccaagaac agatcgctcc caaagacacc tgtcgagatc cccaggaatt gtgtctacca acctaccttc ctatcagaag aggtctctgc tacatctccc agacagcagc atgggggagg aacagaattc cagcatctcc ccatccaatg gagtggagcg aagagcagcc acgctctata gccagtatac atccaagaat gatgaaaaca ggtcctttga gggaacactt tataaaagag gggctttgct gaaaggttgg aagccccgtt ggtttgtttt ggatgtaaca aaacatcagc tgcgctacta tgactcaggt gaggacacaa gctgtaaagg ccacattgat ctggctgaag tagaaatggt catccctgct ggccccagca tgggagcccc aaagcacaca agtgacaagg ctttctttga tctcaagacc agcaaacgtg tgtataactt ctgcgcccag gatggacaga gtgcccagca atggatggac aagatccaga gttgtatctc Protein function: Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2. Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate. [The UniProt Consortium]