SAV1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1152 Sequence: atgctgtccc gaaagaaaac caaaaacgaa gtgtccaagc cggccgaggt gcaggggaag tacgtgaaga aggagacgtc gcctctgctt cggaatctta tgccttcatt catccggcat ggtccaacaa ttccaagacg aactgatatc tgtcttccag attcaagccc taatgccttt tcaacttctg gagatgtagt ttcaagaaac cagagtttcc ttagaactcc aattcaaaga acacctcatg aaataatgag aagagaaagc aacagattat ctgcaccttc ttatcttgcc agaagtctag cagatgtccc tagagagtat ggttcttctc agtcatttgt aacggaagtt agttttgctg ttgaaaatgg agactctggt tcccgatatt attattcaga caattttttt gatggtcaga gaaagcggcc acttggagat cgtgcacatg aagactacag atattatgaa tacaaccatg atctcttcca aagaatgcca cagaatcagg ggaggcatgc ttcaggtatt gggagagttg ctgctacatc tttaggaaat ttgactaacc atggttctga agatttaccc cttcctcctg gctggtctgt ggactggaca atgagaggga gaaaatatta tatagatcat aacacaaata caactcactg gagccatcct cttgagcgag aaggacttcc tcctggatgg gaacgagttg agtcatccga atttggaacc tattatgtag atcacacaaa taagaaggcc caatacaggc atccctgtgc tcctagtgta cctcggtatg atcaaccacc tcctgtcaca taccagccac agcaaactga aagaaatcag tcccttctgg tacctgcaaa tccatatcat actgcagaaa ttcctgactg gcttcaggtt tacgcacgag cccctgtgaa atatgaccac attctgaagt gggaactctt ccagctggct gacctggata cataccaggg aatgctaaag ttgctcttca tgaaagaatt ggagcagatt gttaaaatgt atgaagcata cagacaagcc cttcttacag agttggaaaa ccgaaagcag agacagcagt ggtatgccca acaacatgga aaaaattttt Protein function: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. [The UniProt Consortium]