RNF185 (Vector pENTR223.1, Accession No. BC009504)

Length: 579 Sequence: atggcaagca aggggccctc ggcctctgca tctcctgaga actccagtgc aggggggccc agtgggagca gcaatggcgc tggcgagagc ggagggcagg acagcacttt cgagtgcaac atctgcttgg acacagccaa ggatgccgtc atcagcctgt gtggccacct cttctgttgg ccgtgtttac atcagtggtt ggagaccaga cctaacagac aggtgtgtcc tgtttgcaaa gctggcatca gccgagacaa ggtcatcccc ctctatggaa ggggcagcac tgggcaacag gaccccagag agaagacccc tcctcgtcct caaggacaga ggccagagcc ggagaataga gggggatttc aaggatttgg atttggagat ggtggcttcc agatgtcttt tggaattggg gcatttccct ttgggatatt tgccacagca tttaatataa atgatgggcg gcctcctcca gctgtccctg ggacacccca gtatgtggac gagcagttcc tgtcacgcct cttcctattt gtggccctgg tgatcatgtt ctggctcctg Protein function: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1 (PubMed:21931693). Acts in the endoplasmic reticulum (ER)- associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation (PubMed:27485036). Protects cells from ER stress-induced apoptosis (PubMed:27485036). Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway (PubMed:24019521). Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (PubMed:24019521). [The UniProt Consortium]