RNF144B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 909 Sequence: atgggctcag ctggtaggct ccactatctc gccatgactg ctgaaaatcc cactcctgga gacctggctc cggcccccct catcacttgc aaactctgcc tgtgtgagca gtctctggac aagatgacca cactccagga atgccagtgc atcttttgca cagcttgcct gaaacagtac atgcagctgg caatccgaga aggatgtggg tctcccatca cttgccctga catggtgtgc ctaaaccacg ggaccctgca ggaagctgag attgcctgtt tggtacctgt ggaccagttt caactttatc agaggttaaa atttgaaaga gaagttcatc tggaccccta ccgaacatgg tgtcctgttg cagactgtca gacagtgtgc cctgttgcct cgagtgaccc aggacagcct gtgctggtgg aatgcccttc ttgccacctg aaattctgct cgtgttgcaa ggatgcttgg catgcagagg tctcctgtag agacagtcag cctattgtcc tgccaacaga gcaccgagcc ctctttggga cagatgcaga agcccccatt aagcagtgcc cagtttgccg ggtttatatc gaacgcaatg aaggctgcgc tcagatgatg tgcaaaaact gcaagcatac attttgctgg tactgccttc agaacttgga taatgacatt ttcctcagac attatgacaa agggccatgc aggaataaac ttggccactc aagagcatca gtgatgtgga accgaacaca ggtggtgggg attctcgtag gcttgggcat cattgccttg gttacttccc ccttactcct ggcctcccca tgtataatct gttgtgtctg caagtcctgt cggggcaaga agaaaaagca cgacccatcc Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin- dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death, But, it is not an anti-apoptotic protein per se. [The UniProt Consortium]