RNF128 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1287 Sequence: atggggccgc cgcctggggc cggggtctcc tgccgcggtg gctgcggctt ttccagattg ctggcatggt gcttcctgct ggccctgagt ccgcaggcac ccggttcccg gggggctgaa gcagtgtgga ccgcgtacct caacgtgtcc tggcgggttc cgcacacggg agtgaaccgt acggtgtggg agctgagcga ggagggcgtg tacggccagg actcgccgct ggagcctgtg gctggggtcc tggtaccgcc cgacgggccc ggggcgctta acgcctgtaa cccgcacacg aatttcacgg tgcccacggt ttggggaagc accgtgcaag tctcttggtt ggccctcatc caacgcggcg ggggctgcac cttcgcagac aagatccatc tggcttatga gagaggggcg tctggagccg tcatctttaa cttccccggg acccgcaatg aggtcatccc catgtctcac ccgggtgcag tagacattgt tgcaatcatg atcggcaatc tgaaaggcac aaaaattctg caatctattc aaagaggcat acaagtgaca atggtcatag aagtagggaa aaaacatggc ccttgggtga atcactattc aatttttttc gtttctgtgt ccttttttat tattacggcg gcaactgtgg gctattttat cttttattct gctcgaaggc tacggaatgc aagagctcaa agcaggaagc agaggcaatt aaaggcagat gctaaaaaag ctattggaag gcttcaacta cgcacactga aacaaggaga caaggaaatt ggccctgatg gagatagttg tgctgtgtgc attgaattgt ataaaccaaa tgatttggta cgcatcttaa cgtgcaacca tattttccat aagacatgtg ttgacccatg gctgttagaa cacaggactt gccccatgtg caaatgtgac atactcaaag ctttgggaat tgaggtggat gttgaagatg gatcagtgtc tttacaagtc cctgtatcca atgaaatatc taatagtgcc tcctcccatg aagaggataa tcgcagcgag accgcatcat ctggatatgc ttcagtacag ggaacagatg aaccgcctct ggaggaacac gtgcagtcaa caaatgaaag tctacagctg gtaaaccatg aagcaaattc tgtggcagtg gatgttattc ctcatgttga caacccaacc tttgaagaag acgaaactcc taatcaagag actgctgttc gagaaattaa Protein function: E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down- regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm, sensitizes ectoderm to respond to neural-inducing signals. [The UniProt Consortium]