RNF126 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 981 Sequence: atggccgagg cgtcgccgca tcccggacgg tacttctgcc actgctgctc cgtggagatc gtcccgcgcc tgccggatta tatctgtcca agatgcgagt ctggttttat cgaggagctt ccggaagaga ccaggagcac agaaaatggt tctgccccct ccacagctcc cacagaccag agccggccac cgttggagca cgtggaccag cacctgttca cgctgccgca gggctacgga cagtttgctt tcggcatctt cgatgacagc ttcgagatcc ccacgttccc tcctggggcg caggctgacg acggcaggga ccctgagagc cggcgggaga gagaccatcc gtcccggcac cggtacggcg cccgacagcc ccgcgcccgc ctcaccacgc ggcgggccac cggccggcac gaaggcgtcc ccacgctgga agggatcatc cagcagctcg tcaacggcat catcacgccc gccaccatcc ccagcctggg cccctgggga gtcctgcact caaaccctat ggactacgcc tggggggcca acggcctgga tgccatcatc acacagctcc tcaatcagtt tgaaaacaca ggccccccac cggcagataa agagaaaatc caggccctcc ccaccgtccc cgtcactgag gagcacgtag gctccgggct cgagtgccct gtgtgcaagg acgactacgc gctgggtgag cgtgtgcggc agctgccctg caaccacctg ttccacgacg gctgcatcgt gccctggctg gagcagcacg acagctgccc cgtctgccga aaaagcctca cgggacagaa cacggccacg aacccccctg gcctcactgg ggtgagcttc tcctcctcgt cgtcatcgtc ctcctccagc tcgcccagca acgagaacgc cacatggtcc cctctggggc gtccccagcc tccccgtcct ctgtctaacc tcaccctcta Protein function: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Depending on the associated E2 ligase, mediates 'Lys-48'- and 'Lys-63'- linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515). May also play a role in the endosomal recycling of IGF2R, the cation- independent mannose-6-phosphate receptor (PubMed:24275455). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (PubMed:23026136). May monoubiquitinate AICDA (PubMed:23277564). [The UniProt Consortium]