RNF114 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 687 Sequence: atggcggcgc aacagcggga ctgcgggggt gctgcgcagc tggcggggcc ggcggcggag gctgaccccc taggacgctt cacgtgtccc gtgtgcttag aggtgtacga gaagccggta caggtgccct gcggacacgt cttttgctct gcatgcctgc aggaatgtct gaagccgaag aagcctgtct gtggggtgtg tcgcagcgct ctggcacctg gcgtccgagc cgtggagctc gagcggcaga tcgagagcac agagacttct tgccatggct gccgtaagaa tttcttcctg tccaagatcc ggtcccacgt ggctacttgt tccaaatacc agaattacat catggaaggt gtgaaggcca ccattaagga tgcatctctt cagccaagga atgttccaaa ccgttacacc tttccttgtc cttactgtcc tgagaagaac tttgatcagg aaggacttgt ggaacactgc aaattattcc atagcacgga taccaaatct gtggtttgtc cgatatgtgc ctcgatgccc tggggagacc ccaactaccg cagcgccaac ttcagagagc acatccagcg ccggcaccgg ttttcttatg acacttttgt ggattatgat gttgatgaag aggacatgat gaatcaggtg ttgcagcgct ccatcatcga Protein function: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. [The UniProt Consortium]