RMND5B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1182 Sequence: atggagcagt gtgcgtgcgt ggagagagag ctggacaagg tcctgcagaa gttcctgacc tacgggcagc actgtgagcg gagcctggag gagctgctgc actacgtggg ccagctgcgg gctgagctgg ccagcgcagc cctccagggg acccctctct cagccaccct ctctctggtg atgtcacagt gctgccggaa gatcaaagat acggtgcaga aactggcttc ggaccataag gacattcaca gcagtgtatc ccgagtgggc aaagccattg acaggaactt cgactctgag atctgtggtg ttgtgtcaga tgcggtgtgg gacgcgcggg aacagcagca gcagatcctg cagatggcca tcgtggaaca cctgtatcag cagggcatgc tcagcgtggc cgaggagctg tgccaggaat caacgctgaa tgtggacttg gatttcaagc agcctttcct agagttgaat cgaatcctgg aagccctgca cgaacaagac ctgggtcctg cgttggaatg ggccgtctcc cacaggcagc gcctgctgga actcaacagc tccctggagt tcaagctgca ccgactgcac ttcatccgcc tcttggcagg aggccccgcg aagcagctgg aggccctcag ctatgctcgg cacttccagc cctttgctcg gctgcaccag cgggagatcc aggtgatgat gggcagcctg gtgtacctgc ggctgggctt ggagaagtca ccctactgcc acctgctgga cagcagccac tgggcagaga tctgtgagac ctttacccgg gacgcctgtt ccctgctggg gctttctgtg gagtcccccc ttagcgtcag ctttgcctct ggctgtgtgg cgctgcctgt gttgatgaac atcaaggctg tgattgagca gcggcagtgc actggggtct ggaatcacaa ggacgagtta ccgattgaga ttgaactagg catgaagtgc tggtaccact ccgtgttcgc ttgccccatc ctccgccagc agacgtcaga ttccaaccct cccatcaagc tcatctgtgg ccatgttatc tcccgagatg cactcaataa gctcattaat ggaggaaagc tgaagtgtcc ctactgtccc atggagcaga acccggcaga tgggaaacgc atcatattct Protein function: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). [The UniProt Consortium]