RIC8A (Vector pENTR223.1, Accession No. BC011821)

Length: 1263 Sequence: atggatgttg tactggagtc cctcaagtgc ctgtgcaacc tcgtgctcag cagccctgtg gcacagatgc tggcagcaga ggcccgccta gtggtgaagc tcacagagcg tgtggggctg taccgtgaga ggagcttccc ccacgatgtc cagttctttg acttgcggct cctcttcctg ctaacggcac tccgcaccga tgtgcgccag cagctgtttc aggagctgaa aggagtgcgc ctgctaactg acacactgga gctgacgctg ggggtgactc ctgaagggaa cccacccacg ctccttcctt cccaagagac tgagcgggcc atggagatcc tcaaagtgct cttcaacatc accctggact ccatcaaggg ggaggtggac gaggaagacg ctgcccttta ccgacacctg gggacccttc tccggcactg tgtgatgatc gctactgctg gagaccgcac agaggagttc cacggccacg cagtgaacct cctggggaac ttgcccctca agtgtctgga tgttctcctc accctggagc cacatggaga ctccacggag ttcatgggag tgaatatgga tgtgattcgt gccctcctca tcttcctaga gaagcgtttg cacaagacac acaggctgaa ggagagtgta gctcccgtgc tgagcgtgct gactgaatgt gcccggatgc accgcccagc caggaagttc ctgaaggccc aggtgctgcc ccctctgcgg gatgtgagga cacggcctga ggttggggag atgctgcgga acaagcttgt ccgcctcatg acacacctgg acacagatgt gaagagggtg gctgccgagt tcttgtttgt cctgtgctct gagagtgtgc cccgattcat caagtacaca ggctatggga atgctgctgg ccttctggct gccaggggcc tcatggcagg aggccggccc gagggccagt actcagagga tgaggacaca gacacagatg agtacaagga agccaaagcc agcataaacc ctgtgaccgg gagggtggag gagaagccgc ctaaccctat ggagggcatg acagaggagc agaaggagca cgaggccatg aagctggtga ccatgtttga caagctctcc aggaacagag tcatccagcc aatggggatg agtccccggg gtcatcttac gtccctgcag gatgccatgt gcgagactat ggagcagcag ctctcctcgg accctgactc ggaccctgac Protein function: Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)- alpha-GDP complex. Also acts as an activator for G(q)- alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. [The UniProt Consortium]