RGS20 (Vector pUC, Accession No. BC063490)

Length: 726 Sequence: atgcgcacgg cggacggagg cgagccggcc ggggcttcct ccccggccgg cagggtggac ggtgggctcc agatgggatc agagcggatg gagatgcgga agcggcagat gcccgccgcc caggacacac caggcgccgc cccaggccag cccggagcgg ggagtcgcgg gtccaacgca tgctgcttct gctggtgctg ctgttgtagc tgctcgtgtc tcactgttag aaaccaggaa gatcagaggc ccacaatagc ttcccacgaa ctcagagcag atcttccaac ctgggaagaa agccctgctc ctactctgga agaagtcaac gcctgggctc agtcatttga caaattaatg gtcactccag caggaaggaa tgcattccgt gaattcctcc gaacagaatt cagtgaggaa aatatgctct tctggatggc ctgtgaggaa ctgaaaaagg aagctaataa aaacattatt gaagagaaag caaggataat ctatgaagac tacatttcta tactttctcc taaggaggtg agcttagact cccgggtgag agaagtgatc aacagaaaca tggtggagcc atcccaacac atattcgatg atgctcaact tcagatttac accctgatgc acagagactc atatcctcga ttcatgaact ctgctgtcta taaggacttg cttcagtcct tatcggagaa atctattgaa Protein function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)- i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. [The UniProt Consortium]