RFX3 (Vector pUC, Accession No. BC022191)

Length: 2250 Sequence: atgcagacat cagagactgg gtcggacaca ggctcgacag tgaccttaca aacatctgtg gctagtcaag cagcagtgcc tacgcaggtg gtacagcaag taccagtaca acaacaggta cagcaggtac agactgtgca gcaggtacaa catgtctatc ccgctcaggt gcagtatgtg gaaggaagcg atactgtcta taccaatgga gcaatccgaa caacaacgta tccttacaca gagacacaga tgtacagcca aaatactgga gggaattact ttgatactca agggagttcc gcccaggtga ctaccgtggt ctcatcccac agtatggtgg gcactggtgg gattcagatg ggcgtcacag gaggacaact catcagcagc tctggaggaa cctatctgat cggcaactca atggagaatt ctggtcactc agtgacacac acaactcggg cctccccagc gacaattgaa atggcgattg agacgctgca aaagtctgac ggtctgtcca ctcacagaag ctctcttctc aacagccatc tccagtggct gttggacaat tatgagacag cagaaggagt gagccttccc agaagcactc tgtacaacca ctaccttcga cactgtcagg aacacaaact ggacccagtc aatgctgcct cttttggaaa attaataaga tcaattttta tggggctacg aaccaggaga ttgggcacta gaggaaactc caaataccac tactatggga ttcgtgtcaa gccagattcc cctcttaatc gtctgcaaga agacatgcag tatatggcta tgagacaaca acccatgcaa cagaaacaaa ggtacaagcc tatgcagaaa gtggatgggg ttgcagatgg tttcacagga agtggtcaac agacaggcac atctgttgag caaactgtaa ttgcccaaag ccaacatcat caacagtttt tagatgcatc tcgagcactt ccagagtttg gagaagttga aatctcttct ctgccagatg gtactacctt tgaggatatc aagtcactgc agagtcttta tagagagcac tgtgaggcaa tattggacgt tgttgtgaat cttcaattta gcctgataga aaaattgtgg caaacattct ggcgctattc tccctctact ccaactgatg gcactaccat taccgaatcg agcaatctga gtgaaataga aagtcgactt ccgaaagcaa agctgataac tctgtgcaaa catgagtcta tcctgaaatg gatgtgtaac tgtgaccatg ggatgtacca ggctttggtg gagattctca tccccgacgt ccttagacct attcctagtg ccttgaccca agccattcga aattttgcaa aaagccttga aggttggctt tccaatgcca tgaacaatat tccacagaga atgatacaaa ccaaggttgc cgctgtaagt gcctttgccc agactctgcg aagatacacg tcgcttaatc acctggccca ggcagctcgt gcagtgcttc agaacacttc ccaaatcaac cagatgctta gtgacctcaa ccgtgtcgac tttgccaatg tccaggagca ggcttcctgg gtgtgccagt gtgatgacaa catggttcag agactagaaa cagacttcaa gatgactctt cagcagcaga gcaccctgga gcagtgggct gcgtggcttg acaatgtgat gatgcaagca ctgaaaccct atgaaggaag acccagtttt cctaaagccg ccaggcagtt tctgctaaaa tggtctttct acagctcaat ggttattcgg gacttaacct tacgcagtgc tgctagcttt ggctccttcc acctgatccg tctactctac gacgaatata tgttttactt agtagaacat cgtgttgctc aggcaacagg agagactcct atagcagtca tgggcgagtt tggtgattta aatgccgtgt ctcctggaaa tctggataaa gatgaaggca gtgaagtaga aagtgaaatg gatgaagaac tggatgactc ttcagagcct caagccaaaa gagagaaaac agagctgagc caggcatttc cagtgggctg catgcagcct gttctcgaga ctggcgtgca accaagcctc ctgaatccaa ttcacagcga gcacattgtc acaagtactc agactatcag acagtgcagc gctacaggaa atacctacac Protein function: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430). [The UniProt Consortium]