RAD51AP1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1059 Sequence: atggtgcggc ctgtgagaca taagaaacca gtcaattact cacagtttga ccactctgac agtgatgatg attttgtttc tgcaactgta cctttaaaca agaaatccag aacagcacca aaggagttaa aacaagataa accaaaacct aacttgaaca atctccggaa agaagaaatc ccagtacaag agaaaacccc taaaaaaaga ctccctgaag gtacttttag tattccagct agtgcagtgc cttgtacaaa gatggcttta gatgacaagc tctaccagag agacttagaa gttgcactag ctttatcagt gaaggaactt ccaacagtca ccactaatgt gcagaactct caagataaaa gcattgaaaa acatggcagt agtaaaatag aaacaatgaa taagtctcct catatctcta attgcagtgt agccagtgat tatttagatt tggataagat tactgtggaa gatgatgttg gtggtgttca agggaaaaga aaagcagcat ctaaagctgc agcacagcag aggaagattc ttctggaagg cagtgatggt gatagtgcta atgacactga accagacttt gcacctggtg aagattctga ggatgattct gatttttgtg agagtgagga taatgacgaa gacttctcta tgagaaaaag taaagttaaa gaaattaaaa agaaagaagt gaaggtaaaa tccccagtag aaaagaaaga gaagaaatct aaatccaaat gtaatgcttt ggtgacttcg gtggactctg ctccagctgc cgtcaaatca gaatctcagt ccttgccaaa aaaggtttct ctgtcttcag ataccactag gaaaccatta gaaatacgca gtccttcagc tgaaagcaag aaacctaaat gggtcccacc agcggcatct ggaggtagca gaagtagcag cagcccactg gtggtagtgt ctgtgaagtc tcccaatcag agtctccgcc ttggcttgtc cagattagca cgagttaaac ctttgcatcc aaatgccact Protein function: Structure-specific DNA-binding protein involved in DNA repair by promoting RAD51-mediated homologous recombination (PubMed:17996710, PubMed:17996711, PubMed:20871616, PubMed:25288561, PubMed:26323318). Acts by stimulating D-Loop formation by RAD51: specifically enhances joint molecule formation through its structure-specific DNA interaction and its interaction with RAD51 (PubMed:17996710, PubMed:17996711). Binds single-stranded DNA (ssDNA), double-stranded DNA (dsDNA) and secondary DNA structures, such as D-loop structures: has a strong preference for branched-DNA structures that are obligatory intermediates during joint molecule formation (PubMed:9396801, PubMed:17996711, PubMed:22375013, PubMed:17996710). Cooperates with WDR48/UAF1 to stimulate RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during homologous recombination and DNA repair (PubMed:27463890, PubMed:27239033, PubMed:32350107). WDR48/UAF1 and RAD51AP1 also have a coordinated role in DNA-binding to promote USP1-mediated deubiquitination of FANCD2 (PubMed:31253762). Also involved in meiosis by promoting DMC1-mediated homologous meiotic recombination (PubMed:21307306). Key mediator of alternative lengthening of telomeres (ALT) pathway, a homology-directed repair mechanism of telomere elongation that controls proliferation in aggressive cancers, by stimulating homologous recombination (PubMed:31400850). May also bind RNA, additional evidences are however required to confirm RNA-binding in vivo (PubMed:9396801). [The UniProt Consortium]