RAB3IP (Vector pENTR223.1, Accession No. BC059358)

Length: 948 Sequence: atggctaatg atcccttgga aggcttccat gaagtaaacc ttgcttcacc tacttctccg gaccttcttg gtgtgtatga atcaggaact caagagcaga ctacctcacc aagtgtcatc taccggccac acccttcagc tttatcctct gtacctatcc aggcaaatgc attagatgtt tctgaacttc ctacacaacc cgtgtattca tcccccagac gtttaaattg tgcggaaata tctagtatca gctttcatgt tacagaccca gccccttgct ctacctctgg agtcacagct ggattaacta aattaactac aagaaaggac aactataatg cagagagaga gtttttacag ggtgctacta taacagaggc ttgcgatggc agtgatgata tttttgggtt gagtactgat agtctgtctc gtttacgaag ccaatctgtt ttggaagtta gagaaaaggg ctatgaacga ttaaaagaag aactcgcaaa agctcagagg gaactgaagt taaaagatga agaatgtgag aggctttcaa aagtgcgaga tcaacttgga caggaattgg aagaactcac agctagtcta tttgaggaag ctcataaaat ggtgagagaa gcaaatatca agcaggcaac agcagaaaaa cagctaaaag aagcacaagg aaaaattgat gtacttcaag ctgaagtagc tgcattgaag acacttgtat tgtccagttc tccaacatca cctacgcagg agcctttgcc aggtggaaag acacctttta aaaaggggca tacaagaaat aaaagcacaa gcagtgctat gagtggcagt catcaggacc tcagtgtgat acagccaatt gtaaaagact gcaaagaggt aactcatcaa ggactgtccc ctctgactct gttgatactt gttagttctc Protein function: Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). [The UniProt Consortium]