RAB3IP (Vector pENTR223.1, Accession No. BC015548)

Length: 765 Sequence: atggtgagag aagcaaatat caagcaggca acagcagaaa aacagctaaa agaagcacaa ggaaaaattg atgtacttca agctgaagta gctgcattga agacacttgt attgtccagt tctccaacat cacctacgca ggagcctttg ccaggtggaa agacaccttt taaaaagggg catacaagaa ataaaagcac aagcagtgct atgagtggca gtcatcagga cctcagtgtg atacagccaa ttgtaaaaga ctgcaaagag gctgacttat ccttgtataa tgaattccga ttgtggaagg atgagcccac aatggacagg acgtgtcctt tcttagacaa aatctaccag gaagatatct ttccatgttt aacattctca aaaagtgagt tggcttcagc tgttctggag gctgtggaaa acaatactct aagcattgaa ccagtgggat tacaacctat ccggtttgtg aaagcttctg cagttgaatg cggaggacca aaaaaatgtg ctctcactgg ccagagtaag tcctgtaaac acagaattaa attaggggac tcaagcaact attattatat ttctcctttt tgcagataca ggatcacttc tgtatgtaac ttttttacat acattcgata cattcagcag ggactcgtga aacagcagga tgttgatcag atgttttggg aggttatgca gttgagaaaa gagatgtcat tggcaaagct gggttatttc aaagaggaac Protein function: Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297). [The UniProt Consortium]