PUS7 (Vector pENTR223.1, Accession No. BC005209)

Length: 780 Sequence: atggatttaa tattgaaacc ccgctctgga gctgaaaagg gctacttggt taaatgcaga gaagaatggg caaagaccaa agacccaact gctgccctca gaaaactacc tgtcaaaagg tgtgtggaag ggcagctgct tcgaggactt tcaaaatatg gaatgaagaa tatagtctct gcatttggca taatacccag aaataatcgc ttaatgtata ttcatagcta ccaaagctat gtgtggaata acatggtaag caagaggata gaagactatg gactaaaacc tgttccaggg gacctcgttc tcaaaggagc cacagccacc tatattgagg aagatgatgt taataattac tctatccatg atgtggtaat gcccttgcct ggtttcgatg ttatctaccc aaagcataaa attcaagaag cctacaggga aatgctcaca gctgacaatc ttgatattga caacatgaga cacaaaattc gagattattc cttgtcaggg gcctaccgaa agatcattat tcgtcctcag aatgttagct gggaagtcgt tgcatatgat gatcccaaaa ttccactttt caacacagat gtggacaacc tagaagggaa gacaccacca gtttttgctt ctgaaggcaa atacagggct ctgaaaatgg atttttctct acccccttct acttacgcca ccatggccat tcgagaagtg ctaaaaatgg ataccagtat caagaaccag acgcagctga atacaacctg Protein function: Pseudouridylate synthase that catalyzes pseudouridylation of RNAs (PubMed:28073919, PubMed:29628141, PubMed:30778726). Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex (PubMed:29628141). Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3' (PubMed:28073919). In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types (PubMed:29628141). [The UniProt Consortium]