PTPRH (Vector pUC, Accession No. BC111716)

Length: 3348 Sequence: ATGGCTGGGG CTGGCGGGGG CCTCGGGGTC TGGGGGAACC TGGTGCTGCT GGGCCTGTGC AGCTGGACAG GGGCCAGGGC GCCTGCCCCC AACCCAGGGA GGAACCTGAC AGTGGAGACT CAGACCACCA GCTCCATCTC CCTGAGCTGG GAGGTCCCCG ATGGCCTAGA CTCACAGAAC TCCAACTACT GGGTTCAGTG TACTGGAGAC GGCGGCACAA CAGAGACTCG AAACACAACA GCCACCAACG TCACCGTGGA TGGCCTTGGA CCCGGGTCAT TGTATACGTG TTCTGTGTGG GTGGAGAAAG ACGGAGTAAA TAGCTCTGTG GGGACTGTCA CTACTGCCAC AGCTCCCAAC CCAGTGAGGA ACCTGAGAGT GGAGGCTCAG ACCAACAGCT CCATCGCCCT GACCTGGGAG GTCCCCGACG GCCCAGACCC ACAGAACTCC ACCTACGGGG TTGAGTACAC TGGAGATGGT GGCAGAGCAG GGACTCGAAG CACAGCACAC ACCAACATCA CCGTGGATGG ACTTGAACCC GGGTGTTTGT ATGCGTTTTC CATGTGGGTG GGAAAGAATG GAATCAACAG CTCCCGGGAG ACTCGAAATG CCACCACAGC TCACAACCCA GTGAGGAACC TGAGAGTGGA GGCTCAGACC ACCAGCTCCA TCTCCCTGAG CTGGGAGGTC CCCGATGGCA CAGACCCACA GAACTCCACC TACTGCGTTC AGTGCACTGG AGATGGTGGC AGAACAGAGA CTCGAAACAC AACAGACACC AGAGTCACCG TGGATGGCCT TGGACCCGGG TCATTGTATA CGTGTTCTGT GTGGGTGGAG AAAGACGGAG TAAATAGCTC TGTGGAGATT GTCACTAGTG CCACAGCTCC CAACCCAGTG AGAAACCTGA CAGTGGAGGC TCAGACCAAC AGCTCCATCG CCCTGACCTG GGAGGTCCCC GATGGCCCAG ACCCACAGAA CTCCACCTAC GGGGTTGAGT ACACTGGAGA TGGTGGCAGA GCAGGGACTC GAAGCACAGC ATACACCAAC ATCACCGTGG ATAGACTTGA ACCCGGGTGT TTGTATGTGT TTTCCGTGTG GGTGGGGAAG AATGGAATCA ACAGCTCCCG GGAGACTCGA AATGCCACCA CAGCCCCCAA CCCAGTGAGA AACCTCCATA TGGAGACTCA GACCAACAGC TCCATCGCCC TATGCTGGGA AGTCCCCGAT GGCCCATACC CTCAGGACTA CACCTACTGG GTAGAGTACA CTGGAGACGG TGGTGGCACA GAGACCCGAA ACACAACAAA TACCAGTGTG ACAGCTGAGA GACTTGAGCC CGGAACCTTG TACACATTCT CTGTATGGGC AGAAAAAAAT GGAGCACGTG GCTCCAGGCA GAATGTCAGC ATCTCCACAG TCCCCAACGC AGTGACAAGC CTCAGCAAGC AGGACTGGAC CAACAGCACC ATTGCTTTGC GCTGGACAGC TCCCCAGGGC CCAGGCCAGT CTTCCTACAG CTACTGGGTC TCATGGGTCA GGGAAGGCAT GACTGACCCC AGGACCCAAA GCACCTCAGG TACTGACATC ACCCTAAAGG AACTGGAAGC TGGCAGCCTG TACCACCTCA CCGTCTGGGC CGAGAGGAAT GAGGTCAGAG GCTATAACAG CACCCTCACT GCAGCCACTG CTCCCAATGA GGTCACAGAT CTCCAGAATG AAACTCAGAC TAAGAACTCA GTCATGCTGT GGTGGAAGGC CCCTGGAGAC CCCCACTCTC AGTTGTACGT ATACTGGGTC CAGTGGGCCA GCAAGGGACA TCCCCGGAGG GGGCAAGATC CCCAAGCGAA TTGGGTCAAC CAGACCAGCA GGACCAATGA GACGTGGTAC AAAGTGGAGG CCCTGGAACC CGGGACGCTG TACAATTTCA CCGTGTGGGC AGAGAGGAAT GACGTAGCCA GTTCCACGCA GAGCCTCTGT GCGTCCACAT ACCCAGACAC AGTCACCATC ACTTCCTGTG TCAGCACCTC AGCGGGCTAT GGAGTCAACT TGATCTGGTC CTGCCCCCAG GGAGGCTACG AGGCCTTTGA GTTGGAGGTG GGAGGACAGC GGGGCTCCCA GGACAGATCT TCATGTGGGG AGGCTGTGTC TGTGTTGGGT CTCGGGCCGG CTCGGTCCTA CCCAGCCACC ATCACGACCA TCTGGGACGG AATGAAGGTC GTGTCTCACT CTGTGGTCTG CCACACCGAG AGTGCAGGGG TCATTGCCGG AGCCTTTGTG GGCATCCTCC TGTTTCTCAT CCTCGTGGGC CTGCTGATTT TCTTCCTGAA GAGGAGGAAT AAGAAGAAGC AGCAGAAACC AGAACTCAGG GATCTGGTCT TTAGCTCCCC AGGGGACATC CCAGCTGAAG ACTTCGCTGA CCACGTCAGG AAGAATGAGA GGGACAGCAA CTGTGGTTTT GCAGACGAGT ACCAGCAACT CTCCCTGGTG GGCCACAGCC AGTCTCAGAT GGTGGCTTCG GCTTCAGAGA ACAACGCCAA GAACCGCTAC AGAAATGTGC TGCCCTATGA CTGGTCCCGG GTGCCCCTGA AGCCCATCCA TGAGGAGCCA GGCTCTGACT ACATCAATGC CAGCTTCATG CCCGGTCTCT GGAGCCCCCA GGAGTTCATT GCAACCCAGG GTCCCCTGCC ACAGACAGTG GGTGACTTCT GGCGCCTGGT GTGGGAACAG CAGAGCCACA CCCTGGTCAT GCTGACCAAC TGCATGGAGG CCGGCCGGGT GAAGTGTGAG CATTACTGGC CTCTGGACTC GCAGCCCTGC ACCCATGGGC ACCTGCGGGT AACCCTGGTA GGTGAGGAAG TGATGGAGAA CTGGACGGTG CGGGAACTGC TGCTCCTCCA GGTGGAGGAG CAGAAGACAC TGTCTGTGCG CCAATTCCAC TACCAGGCCT GGCCGGATCA CGGCGTTCCC TCCTCCCCAG ACACCTTGCT GGCTTTCTGG AGGATGCTTC GGCAGTGGCT GGATCAGACC ATGGAGGGAG GCCCACCCAT TGTGCACTGC AGTGCTGGCG TGGGTCGCAC AGGAACCCTC ATTGCCCTGG ACGTCCTGCT CCGGCAGCTG CAGTCCGAGG GTCTCCTTGG GCCCTTCAGC TTTGTAAGGA AGATGAGAGA GAGTCGGCCG TTGATGGTGC AGACTGAGGC TCAGTACGTA TTCCTGCATC AGTGCATCCT GCGGTTCCTC CAACAGTCAG CCCAGGCCCC AGCCGAGAAG GAAGTCCCGT ATGAGGATGT CGAAAACCTC ATCTACGAGA ACGTGGCCGC CATCCAGGCC CACAAGTTGG Protein function: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin- promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20. [The UniProt Consortium]