PTPRB (Vector pUC, Accession No. BC113463)

Length: 5994 Sequence: ATGCTGAGCC ATGGAGCCGG GTTGGCCTTG TGGATCACAC TGAGCCTGCT GCAGACTGGA CTGGCGGAGC CAGAGAGATG TAACTTCACC CTGGCGGAGT CCAAGGCCTC CAGCCATTCT GTGTCTATCC AGTGGAGAAT TTTGGGCTCA CCCTGTAACT TTAGCCTCAT CTATAGCAGT GACACCCTGG GGGCCGCGTT GTGCCCTACC TTTCGGATAG ACAACACCAC ATACGGATGT AACCTTCAAG ATTTACAAGC AGGAACCATC TATAACTTCA AGATTATTTC TCTGGATGAA GAGAGAACTG TGGTCTTGCA AACAGATCCT TTACCTCCTG CTAGGTTTGG AGTCAGTAAA GAGAAGACGA CTTCAACCAG CTTGCATGTT TGGTGGACTC CTTCTTCCGG AAAAGTCACC TCATATGAGG TGCAATTATT TGATGAAAAT AACCAGAAGA TACAGGGGGT TCAAATTCAA GAAAGTACTT CATGGAATGA ATACACTTTT TTCAATCTCA CTGCTGGTAG TAAATACAAT ATTGCCATCA CAGCTGTTTC TGGAGGAAAA CGTTCTTTTT CAGTTTATAC CAATGGATCA ACAGTGCCAT CTCCAGTGAA AGATATTGGT ATTTCCACAA AAGCCAATTC TCTCCTGATT TCCTGGTCCC ATGGTTCTGG GAATGTGGAA CGATACCGGC TGATGCTAAT GGATAAAGGG ATCCTAGTTC ATGGCGGTGT TGTGGACAAA CATGCTACTT CCTATGCTTT TCACGGGCTG ACCCCTGGCT ACCTCTACAA CCTCACTGTT ATGACTGAGG CTGCAGGGCT GCAAAACTAC AGGTGGAAAC TAGTCAGGAC AGCCCCCATG GAAGTCTCAA ATCTGAAGGT GACAAATGAT GGCAGTTTGA CCTCTCTAAA AGTCAAATGG CAAAGACCTC CTGGAAATGT GGATTCTTAC AATATCACCC TGTCTCACAA AGGGACCATC AAGGAATCCA GAGTATTAGC ACCTTGGATT ACTGAAACTC ACTTTAAAGA GTTAGTCCCC GGTCGACTTT ATCAAGTTAC TGTCAGCTGT GTCTCTGGTG AACTGTCTGC TCAGAAGATG GCAGTGGGCA GAACATTTCC AGACAAAGTT GCAAACCTGG AGGCAAACAA TAATGGCAGG ATGAGGTCTC TTGTAGTGAG CTGGTCGCCC CCTGCTGGAG ACTGGGAGCA GTATCGGATC CTACTCTTCA ATGATTCTGT GGTGCTGCTC AACATCACTG TGGGAAAGGA AGAAACACAG TATGTCATGG ATGACACGGG GCTCGTACCG GGAAGACAGT ATGAGGTGGA AGTCATTGTT GAGAGTGGAA ATTTGAAGAA TTCTGAGCGT TGCCAAGGCA GGACAGTCCC CCTGGCTGTC CTCCAGCTTC GTGTCAAACA TGCCAATGAA ACCTCACTGA GTATCATGTG GCAGACCCCT GTAGCAGAAT GGGAGAAATA CATCATTTCC CTAGCTGACA GAGACCTCTT ACTGATCCAC AAGTCACTCT CCAAAGATGC CAAAGAATTC ACTTTTACTG ACCTGGTGCC TGGACGAAAA TACATGGCTA CAGTCACCAG TATTAGTGGA GACTTAAAAA ATTCCTCTTC AGTAAAAGGA AGAACAGTGC CTGCCCAAGT GACTGACTTG CATGTGGCCA ACCAAGGAAT GACCAGTAGT CTGTTTACTA ACTGGACCCA GGCACAAGGA GACGTAGAAT TTTACCAAGT CTTACTGATC CATGAAAATG TGGTCATTAA AAATGAAAGC ATCTCCAGTG AGACCAGCAG ATACAGCTTC CACTCTCTCA AGTCCGGCAG CCTGTACTCC GTGGTGGTAA CAACAGTGAG TGGAGGGATC TCTTCCCGAC AAGTGGTTGT GGAGGGAAGA ACAGTCCCTT CCAGTGTGAG TGGAGTAACG GTGAACAATT CCGGTCGTAA TGACTACCTC AGCGTTTCCT GGCTGCTGGC GCCCGGAGAT GTGGATAACT ATGAGGTAAC ATTGTCTCAT GACGGCAAGG TGGTTCAGTC CCTTGTCATT GCCAAGTCTG TCAGAGAATG TTCCTTCAGC TCCCTCACCC CAGGCCGCCT CTACACCGTG ACCATAACTA CAAGGAGTGG CAAGTATGAA AATCACTCCT TCAGCCAAGA GCGGACAGTG CCTGACAAAG TCCAGGGAGT CAGTGTTAGC AACTCAGCCA GGAGTGACTA TTTAAGGGTA TCCTGGGTGC ATGCCACTGG AGACTTTGAT CACTATGAAG TCACCATTAA AAACAAAAAC AACTTCATTC AAACTAAAAG CATTCCCAAG TCAGAAAACG AATGTGTATT TGTTCAGCTA GTCCCTGGAC GGTTGTACAG TGTCACTGTT ACTACAAAAA GTGGACAATA TGAAGCCAAT GAACAAGGGA ATGGGAGAAC AATTCCAGAG CCTGTTAAGG ATCTAACATT GCGCAACAGG AGCACTGAGG ACTTGCATGT GACTTGGTCA GGAGCTAATG GGGATGTCGA CCAATATGAG ATCCAGCTGC TCTTCAATGA CATGAAAGTA TTTCCTCCTT TTCACCTTGT AAATACCGCA ACCGAGTATC GATTTACTTC CCTAACACCA GGCCGCCAAT ACAAAATTCT TGTCTTGACG ATTAGCGGGG ATGTACAGCA GTCAGCCTTC ATTGAGGGCT TCACAGTTCC TAGTGCTGTC AAAAATATTC ACATTTCTCC CAATGGAGCA ACAGATAGCC TGACGGTGAA CTGGACTCCT GGTGGGGGAG ACGTTGATTC CTACACGGTG TCGGCATTCA GGCACAGTCA AAAGGTTGAC TCTCAGACTA TTCCCAAGCA CGTCTTTGAG CACACGTTCC ACAGACTGGA GGCCGGGGAG CAGTACCAGA TCATGATTGC CTCAGTCAGC GGGTCCCTGA AGAATCAGAT AAATGTGGTT GGGCGGACAG TTCCAGCATC TGTCCAAGGA GTAATTGCAG ACAATGCATA CAGCAGTTAT TCCTTAATAG TAAGTTGGCA AAAAGCTGCT GGTGTGGCAG AAAGATATGA TATCCTGCTT CTAACTGAAA ATGGAATCCT TCTGCGCAAC ACATCAGAGC CAGCCACCAC TAAGCAACAC AAATTTGAAG ATCTAACACC AGGCAAGAAA TACAAGATAC AGATCCTAAC TGTCAGTGGA GGCCTCTTTA GCAAGGAAGC CCAGACTGAA GGCCGAACAG TCCCAGCAGC TGTCACCGAC CTGAGGATCA CAGAGAACTC CACCAGGCAC CTGTCCTTCC GCTGGACCGC CTCAGAGGGG GAGCTCAGCT GGTACAACAT CTTTTTGTAC AACCCAGATG GGAATCTCCA GGAGAGAGCT CAAGTTGACC CACTAGTCCA GAGCTTCTCT TTCCAGAACT TGCTACAAGG CAGAATGTAC AAGATGGTGA TTGTAACTCA CAGTGGGGAG CTGTCTAATG AGTCTTTCAT ATTTGGTAGA ACAGTCCCAG CCTCTGTGAG TCATCTCAGG GGGTCCAATC GGAACACGAC AGACAGCCTT TGGTTCAACT GGAGTCCAGC CTCTGGGGAC TTTGACTTTT ATGAGCTGAT TCTCTATAAT CCCAATGGCA CAAAGAAGGA AAACTGGAAA GACAAGGACC TGACGGAGTG GCGGTTTCAA GGCCTTGTTC CTGGAAGGAA GTACGTGCTG TGGGTGGTAA CTCACAGTGG AGATCTCAGC AATAAAGTCA CAGCGGAGAG CAGAACAGCT CCAAGTCCTC CCAGTCTCAT GTCATTTGCT GACATTGCAA ACACATCCTT GGCCATCACG TGGAAAGGGC CCCCAGACTG GACAGACTAC AACGACTTTG AGCTGCAGTG GTTGCCCAGA GATGCACTTA CTGTCTTCAA CCCCTACAAC AACAGAAAAT CAGAAGGACG CATTGTGTAT GGTCTTCGTC CAGGGAGATC CTATCAATTC AACGTCAAGA CTGTCAGTGG TGATTCCTGG AAAACTTACA GCAAACCAAT TTTTGGATCT GTGAGGACAA AGCCTGACAA GATACAAAAC CTGCATTGCC GGCCTCAGAA CTCCACGGCC ATTGCCTGTT CTTGGATCCC TCCTGATTCT GACTTTGATG GTTATAGTAT TGAATGCCGG AAAATGGACA CCCAAGAAGT TGAGTTTTCC AGAAAGCTGG AGAAAGAAAA ATCTCTGCTC AACATCATGA TGCTAGTGCC CCATAAGAGG TACCTGGTGT CCATCAAAGT GCAGTCGGCC GGCATGACCA GCGAGGTGGT TGAAGACAGC ACTATCACAA TGATAGACCG CCCCCCTCCT CCACCCCCAC ACATTCGTGT GAATGAAAAG GATGTGCTAA TTAGCAAGTC TTCCATCAAC TTTACTGTCA ACTGCAGCTG GTTCAGCGAC ACCAATGGAG CTGTGAAATA CTTCACAGTG GTGGTGAGAG AGGCTGATGG CAGTGATGAG CTGAAGCCAG AACAGCAGCA CCCTCTCCCT TCCTACCTGG AGTACAGGCA CAATGCCTCC ATTCGGGTGT ATCAGACTAA TTATTTTGCC AGCAAATGTG CCGAAAATCC TAACAGCAAC TCCAAGAGTT TTAACATTAA GCTTGGAGCA GAGATGGAGA GCCTAGGTGG AAAATGCGAT CCCACTCAGC AAAAATTCTG TGATGGACCA CTGAAGCCAC ACACTGCCTA CAGAATCAGC ATTCGAGCTT TTACACAGCT CTTTGATGAG GACCTGAAGG AATTCACAAA GCCACTCTAT TCAGACACAT TTTTTTCTTT ACCCATCACT ACTGAATCAG AGCCCTTGTT TGGAGCTATT GAAGGTGTGA GTGCTGGTCT GTTTTTAATT GGCATGCTAG TGGCTGTTGT TGCCTTATTG ATCTGCAGAC AGAAAGTGAG CCATGGTCGA GAAAGACCCT CTGCCCGTCT GAGCATTCGT AGGGATCGAC CATTATCTGT CCACTTAAAC CTGGGCCAGA AAGGTAACCG GAAAACTTCT TGTCCAATAA AAATAAATCA GTTTGAAGGG CATTTCATGA AGCTACAGGC TGACTCCAAC TACCTTCTAT CCAAGGAATA CGAGGAGTTA AAAGACGTGG GCCGAAACCA GTCATGTGAC ATTGCACTCT TGCCGGAGAA TAGAGGGAAA AATCGATACA ACAATATATT GCCCTATGAT GCCACGCGAG TGAAGCTCTC CAATGTAGAT GATGATCCTT GCTCTGACTA CATCAATGCC AGCTACATCC CTGGCAACAA CTTCAGAAGA GAATACATTG TCACTCAGGG ACCGCTTCCT GGCACCAAGG ATGACTTCTG GAAAATGGTG TGGGAACAAA ACGTTCACAA CATCGTCATG GTGACCCAGT GTGTTGAGAA GGGCCGAGTA AAGTGTGACC ATTACTGGCC AGCGGACCAG GATTCCCTCT ACTATGGGGA CCTCATCCTG CAGATGCTCT CAGAGTCCGT CCTGCCTGAG TGGACCATCC GGGAGTTTAA GATATGCGGT GAGGAACAGC TTGATGCACA CAGACTCATC CGCCACTTTC ACTATACGGT GTGGCCAGAC CATGGAGTCC CAGAAACCAC CCAGTCTCTG ATCCAGTTTG TGAGAACTGT CAGGGACTAC ATCAACAGAA GCCCGGGTGC TGGGCCCACT GTGGTGCACT GCAGTGCTGG TGTGGGTAGG ACTGGAACCT TTATTGCATT GGACCGAATC CTCCAGCAGT TAGACTCCAA AGACTCTGTG GACATTTATG GAGCAGTGCA CGACCTAAGA CTTCACAGGG TTCACATGGT CCAGACTGAG TGTCAGTATG TCTACCTACA TCAGTGTGTA AGAGATGTCC TCAGAGCAAG AAAGCTACGG AGTGAACAAG AAAACCCCTT GTTTCCAATC TATGAAAATG TGAATCCAGA GTATCACAGA GATCCAGTCT ATTCAAGGCA Protein function: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. [The UniProt Consortium]