PTPN23 (Vector pUC, Accession No. BC089042)

Length: 4911 Sequence: ATGGAGGCCG TGCCCCGCAT GCCCATGATC TGGCTGGACC TGAAGGAGGC CGGTGACTTT CACTTCCAGC CAGCTGTGAA GAAGTTTGTC CTGAAGAATT ATGGAGAGAA CCCAGAAGCC TACAATGAAG AACTGAAGAA GCTGGAGTTG CTCAGACAGA ATGCTGTCCG TGTCCCACGA GACTTTGAGG GCTGTAGTGT CCTCCGCAAG TACCTCGGCC AGCTTCATTA CCTGCAGAGT CGGGTCCCCA TGGGCTCGGG CCAGGAGGCC GCTGTCCCTG TCACCTGGAC AGAGATCTTC TCAGGCAAGT CTGTGGCCCA TGAGGACATC AAGTACGAGC AGGCCTGTAT TCTCTACAAC CTTGGAGCGC TGCACTCCAT GCTGGGGGCC ATGGACAAGC GGGTGTCTGA GGAGGGCATG AAGGTCTCCT GTACCCATTT CCAGTGCGCA GCCGGCGCCT TCGCCTACCT ACGGGAGCAC TTCCCTCAAG CCTACAGCGT CGACATGAGC CGCCAGATCC TTACGCTCAA CGTCAACCTC ATGCTGGGCC AGGCTCAGGA GTGCCTCCTG GAGAAGTCGA TGTTGGACAA CAGGAAGAGC TTTCTGGTGG CCCGCATCAG TGCACAGGTG GTAGATTACT ACAAGGAGGC ATGCCGGGCC TTGGAGAACC CCGACACTGC CTCACTGCTG GGCCGGATCC AGAAGGACTG GAAGAAACTT GTGCAGATGA AGATCTACTA CTTCGCAGCC GTGGCTCATC TGCACATGGG AAAGCAGGCC GAGGAGCAGC AGAAGTTCGG GGAGCGGGTT GCATACTTCC AGAGCGCCCT GGACAAGCTC AATGAAGCCA TCAAGTTGGC CAAGGGCCAG CCTGACACTG TGCAAGACGC GCTTCGCTTC ACTATGGATG TCATTGGGGG AAAGTACAAT TCTGCCAAGA AGGACAACGA CTTCATTTAC CATGAGGCTG TCCCAGCATT GGACACCCTT CAGCCTGTAA AAGGAGCCCC CTTGGTGAAG CCCTTGCCAG TGAACCCCAC AGACCCAGCT GTTACAGGCC CTGACATCTT TGCCAAACTG GTACCCATGG CTGCCCACGA GGCCTCGTCA CTGTACAGTG AGGAGAAGGC CAAGCTGCTC CGGGAGATGA TGGCCAAGAT TGAGGACAAG AATGAGGTCC TGGACCAGTT CATGGATTCA ATGCAGTTGG ATCCCGAGAC GGTGGACAAC CTTGATGCCT ACAGCCACAT CCCACCCCAG CTCATGGAGA AGTGCGCGGC TCTCAGCGTC CGGCCCGACA CTGTCAGGAA CCTTGTACAG TCCATGCAAG TGCTGTCAGG TGTGTTCACG GATGTGGAGG CTTCCCTGAA GGACATCAGA GATCTGTTGG AGGAGGATGA GCTGCTAGAG CAGAAGTTTC AGGAGGCGGT GGGCCAGGCA GGGGCCATCT CCATCACCTC CAAGGCTGAG CTGGCAGAGG TGAGGCGAGA ATGGGCCAAG TACATGGAAG TCCATGAGAA GGCCTCCTTC ACCAACAGTG AGCTGCACCG TGCCATGAAC CTGCACGTCG GCAACCTGCG CCTGCTCAGC GGGCCGCTTG ACCAGGTCCG GGCTGCCCTG CCCACACCGG CCCTCTCCCC AGAGGACAAG GCCGTGCTGC AAAACCTAAA GCGCATCCTG GCTAAGGTGC AGGAGATGCG GGACCAGCGC GTGTCCCTGG AGCAGCAGCT GCGTGAGCTT ATCCAGAAAG ATGACATCAC TGCCTCGCTG GTCACCACAG ACCACTCAGA GATGAAGAAG TTGTTCGAGG AGCAGCTGAA AAAGTATGAC CAGCTGAAGG TGTACCTGGA GCAGAACCTG GCCGCCCAGG ACCGTGTCCT CTGTGCACTG ACAGAGGCCA ACGTGCAGTA CGCAGCCGTG CGGCGGGTAC TCAGCGACTT GGACCAAAAG TGGAACTCCA CGCTGCAGAC CCTGGTGGCC TCGTATGAAG CCTATGAGGA CCTGATGAAG AAGTCGCAGG AGGGCAGGGA CTTCTACGCA GATCTGGAGA GCAAGGTGGC TGCTCTGCTG GAGCGCACGC AGTCCACCTG CCAGGCCCGC GAGGCTGCCC GCCAGCAGCT CCTGGACAGG GAGCTGAAGA AGAAGCCGCC GCCACGGCCC ACAGCCCCAA AGCCGCTGCT GCCCCGCAGG GAGGAGAGTG AGGCAGTGGA AGCAGGAGAC CCCCCTGAGG AGCTGCGCAG CCTCCCCCCT GACATGGTGG CTGGCCCACG ACTGCCTGAC ACCTTCCTGG GAAGTGCCAC CCCGCTCCAC TTTCCTCCCA GCCCCTTCCC CAGCTCCACA GGCCCAGGAC CCCACTATCT CTCAGGCCCC TTGCCCCCTG GTACCTACTC GGGCCCCACC CAGCTGATAC AGCCCAGGGC CCCAGGGCCC CATGCAATGC CCGTAGCACC TGGGCCTGCC CTCTACCCAG CCCCTGCCTA CACACCGGAG CTGGGCCTTG TGCCCCGATC CTCCCCACAG CATGGCGTGG TGAGCAGTCC CTATGTGGGG GTAGGGCCGG CCCCACCAGT TGCAGGTCTC CCCTCGGCCC CACCTCCTCA ATTCTCAGGC CCCGAGTTGG CCATGGCGGT TCGGCCAGCC ACCACCACAG TAGATAGCAT CCAGGCGCCC ATCCCCAGCC ACACAGCCCC ACGGCCAAAC CCCACCCCTG CTCCTCCCCC GCCCTGCTTC CCTGTGCCCC CACCGCAGCC ACTGCCCACG CCTTACACCT ACCCTGCAGG GGCTAAGCAA CCCATCCCAG CACAGCACCA CTTCTCTTCT GGGATCCCCG CAGGTTTTCC AGCCCCAAGG ATTGGGCCCC AGCCCCAGCC CCATCCTCAG CCCCATCCTT CACAAGCGTT TGGGCCTCAG CCCCCACAGC AGCCCCTTCC ACTCCAGCAT CCACATCTCT TCCCACCCCA GGCCCCAGGA CTCCTACCCC CACAATCCCC CTACCCCTAT GCCCCTCAGC CTGGGGTCCT GGGGCAGCCG CCACCCCCCC TACACACCCA GCTCTACCCA GGTCCCGCTC AAGACCCTCT GCCAGCCCAC TCAGGGGCTC TGCCTTTCCC CAGCCCTGGG CCCCCTCAGC CTCCCCATCC CCCACTGGCA TATGGTCCTG CCCCTTCTAC CAGACCCATG GGCCCCCAGG CAGCCCCTCT TACCATTCGA GGGCCCTCGT CTGCTGGCCA GTCCACCCCT AGTCCCCACC TGGTGCCTTC ACCTGCCCCA TCTCCAGGGC CTGGTCCGGT ACCCCCTCGC CCCCCAGCAG CAGAACCACC CCCTTGCCTG CGCCGAGGCG CCGCAGCTGC AGACCTGCTC TCCTCCAGCC CGGAGAGCCA GCATGGCGGC ACTCAGTCTC CTGGGGGTGG GCAGCCCCTG CTGCAGCCCA CCAAGGTGGA TGCAGCTGAG GGTCGTCGGC CGCAGGCCCT GCGGCTGATT GAGCGGGACC CCTATGAACA TCCTGAGAGG CTGCGGCAGT TGCAGCAGGA GCTGGAGGCC TTTCGGGGTC AGCTGGGGGA TGTGGGAGCT CTGGACACTG TCTGGCGAGA GCTGCAAGAT GCGCAGGAAC ATGATGCCCG AGGCCGTTCC ATCGCCATTG CCCGCTGCTA CTCACTGAAG AACCGGCACC AGGATGTCAT GCCCTATGAC AGTAACCGTG TGGTGCTGCG CTCAGGCAAG GATGACTACA TCAATGCCAG CTGCGTGGAG GGGCTCTCCC CATACTGCCC CCCGCTAGTG GCAACCCAGG CCCCACTGCC TGGCACAGCT GCTGACTTCT GGCTCATGGT CCATGAGCAG AAAGTGTCAG TCATTGTCAT GCTGGTTTCT GAGGCTGAGA TGGAGAAGCA AAAAGTGGCA CGCTACTTCC CCACCGAGAG GGGCCAGCCC ATGGTGCACG GTGCCCTGAG CCTGGCATTG AGCAGCGTCC GCAGCACCGA AACCCATGTG GAGCGCGTGC TGAGCCTGCA GTTCCGAGAC CAGAGCCTCA AGCGCTCTCT TGTGCACCTG CACTTCCCCA CTTGGCCTGA GTTAGGCCTG CCCGACAGCC CCAGCAACTT GCTGCGCTTC ATCCAGGAGG TGCACGCACA TTACCTGCAT CAGCGGCCGC TGCACACGCC CATCATTGTG CACTGCAGCT CTGGTGTGGG CCGCACGGGA GCCTTTGCAC TGCTCTATGC AGCTGTGCAG GAGGTGGAGG CTGGGAACGG AATCCCTGAG CTGCCTCAGC TGGTGCGGCG CATGCGGCAG CAGAGAAAGC ACATGCTGCA GGAGAAGCTG CACCTCAGGT TCTGCTATGA GGCAGTGGTG AGACACGTGG AGCAGGTCCT GCAGCGCCAT GGTGTGCCTC CTCCATGCAA ACCCTTGGCC AGTGCAAGCA TCAGCCAGAA GAACCACCTT CCTCAGGACT CCCAGGACCT GGTCCTCGGT GGGGATGTGC CCATCAGCTC CATCCAGGCC ACCATTGCCA AGCTCAGCAT TCGGCCTCCT GGGGGGTTGG AGTCCCCGGT TGCCAGCTTG CCAGGCCCTG CAGAGCCCCC AGGCCTCCCG CCAGCCAGCC TCCCAGAGTC TACCCCAATC CCATCTTCCT CCCCACCCCC CCTTTCCTCC CCACTACCTG AGGCTCCCCA GCCTAAGGAG GAGCCGCCAG TGCCTGAAGC CCCCAGCTCG GGGCCCCCCT CCTCCTCCCT GGAATTGCTG GCCTCCTTGA CCCCAGAGGC CTTCTCCCTG GACAGCTCCC TGCGGGGCAA ACAGCGGATG AGCAAGCATA ACTTTCTGCA GGCCCATAAC GGGCAAGGGC TGCGGGCCAC CCGGCCCTCT GACGACCCCC TCAGCCTTCT GGATCCACTC TGGACACTCA ACAAGACCTG Protein function: Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes (PubMed:18434552, PubMed:21757351). May act as a negative regulator of Ras-mediated mitogenic activity (PubMed:18434552). Plays a role in ciliogenesis (PubMed:20393563). [The UniProt Consortium]