PTPLA (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 867 Sequence: atggggcgcc tgacggaagc ggcggcagcg ggcagcggct ctcgggctgc aggctgggca gggtcccctc ccacgctcct gccgctgtct cccacgtccc ccaggtgcgc ggccaccatg gcgtccagcg acgaggacgg caccaacggc ggcgcctcgg aggccggcga ggaccgggag gctcccggca agcggaggcg cctggggttc ttggccaccg cctggctcac cttctacgac atcgccatga ccgcggggtg gttggttcta gctattgcca tggtacgttt ttatatggaa aaaggaacac acagaggttt atataaaagt attcagaaga cacttaaatt tttccagaca tttgccttgc ttgagatagt tcactgttta attggaattg tacctacttc tgtgattgtg actggggtcc aagtgagttc aagaatcttt atggtgtggc tcattactca cagtataaaa ccaatccaga atgaagagag tgtggtgctt tttctggtcg cgtggactgt gacagagatc actcgctatt ccttctacac attcagcctt cttgaccact tgccatactt cattaaatgg gccagatata atttttttat catcttatat cctgttggag ttgctggtga acttcttaca atatacgctg ccttgccgca tgtgaagaaa acaggaatgt tttcaataag acttcctaac aaatacaatg tctcttttga ctactattat tttcttctta taaccatggc atcatatata cctttgtttc cacaactcta ttttcatatg ttacgtcaaa gaagaaaggt gcttcatgga gaggtgattg tagaaaagga Protein function: [Isoform 1]: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. [The UniProt Consortium]