PSTPIP1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1251 Sequence: atgatgcccc agctgcagtt caaagatgcc ttttggtgca gggacttcac agcccacacg ggctacgagg tgctgctgca gcggcttctg gatggcagga agatgtgcaa agacatggag gagctactga ggcagagggc ccaggcggag gagcggtacg ggaaggagct ggtgcagatc gcacggaagg caggtggcca gacggagatc aactccctga gggcctcctt tgactccttg aagcagcaaa tggagaatgt gggcagctca cacatccagc tggccctgac cctgcgtgag gagctgcgga gtctcgagga gtttcgtgag aggcagaagg agcagaggaa gaagtatgag gccgtcatgg accgggtcca gaagagcaag ctgtcgctct acaagaaggc catggagtcc aagaagacat acgagcagaa gtgccgggac gcggacgacg cggagcaggc cttcgagcgc attagcgcca acggccacca gaagcaggtg gagaagagtc agaacaaagc caggcagtgc aaggactcgg ccaccgaggc agagcgggta tacaggcaga gcattgcgca gctggagaag gtccgggctg agtgggagca ggagcaccgg accacctgtg aggcctttca gctgcaagag tttgaccggc tgaccattct ccgcaacgcc ctgtgggtgc acagcaacca gctctccatg cagtgtgtca aggatgatga gctctacgag gaagtgcggc tgacgctgga aggctgcagc atagacgccg acatcgacag tttcatccag gccaagagca cgggcacaga gccccccgct ccggtgccct accagaacta ttacgatcgg gaggtcaccc cgctgaccag cagccctggc atacagccgt cctgcggcat gataaagagg ttctctggac tgctgcacgg aagtcccaag accacttcgt tggcagcttc tgctgcgtcc acagagaccc tgacccccac ccccgagcgg aatgagggtg tctacacagc catcgcagtg caggagatac agggaaaccc ggcctcacca gcccaggagt accgggcgct ctacgattat acagcgcaga acccagatga gctggacctg tccgcgggag acatcctgga ggtgatcctg gaaggggagg atggctggtg gactgtggag aggaacgggc agcgtggctt cgtccctggt tcctacctgg agaagctttg Protein function: Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T- cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils. [The UniProt Consortium]