PSME4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 648 Sequence: atgtctcagg ggttgcttta ccctcatcaa gtgcctttgg tacttcaggt gctaaaacaa acagcaagaa gcagttcttg gcatgcacga tacacagtac tgacctacct ccagaccatg gtattttata acctctttat tttcctaaac aatgaagatg cagttaaaga tatcaggtgg ctggttataa gtcttttgga ggacgaacaa ctggaggttc gagaaatggc tgctactacc ttaagcggtc tgctacagtg taactttctt accatggaca gtcctatgca gattcatttt gagcaacttt gcaaaacaaa actacctaag aaaagaaagc gagaccctgg ttctgtagga gataccattc cttctgcaga gttggtcaaa cgccatgctg gggtgctagg acttggtgca tgtgttcttt ctagtcctta cgatgttccc acctggatgc cccagctcct catgaatctc agtgcacatc taaatgatcc tcagcctatt gagatgactg taaaaaaaac cttatccaat ttccgaagga ctcaccatga caactggcag gaacataaac agcaattcac tgatgaccaa ctgcttgttc tcaccgatct tcttgtgtca ccatgctatt Protein function: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks. [The UniProt Consortium]