PRX (Vector pUC, Accession No. BC067266)

Length: 4386 Sequence: atggaggcca ggagccggag tgccgaggag ctgaggcggg cggagttggt ggaaattatc gtggagacgg aggcgcagac cggggtcagc ggcatcaacg tagcgggcgg cggcaaagag ggaatcttcg ttcgggagct gcgcgaggac tcacccgccg ccaggagcct cagcctgcag gaaggggacc agctgctgag tgcccgagtg ttcttcgaga acttcaagta cgaggacgca ctacgcctgc tgcaatgcgc cgagccttac aaagtctcct tctgcctgaa gcgcactgtg cccaccgggg acctggctct gcggcccggg accgtgtctg gctacgagat caagggcccg cgggccaagg tggccaagct gaacatccag agtctgtccc ctgtgaagaa gaagaagatg gtgcctgggg ctctgggggt ccccgctgac ctggcccctg ttgacgtcga gttctccttt cccaagttct cccgcctgcg tcggggcctc aaagccgagg ctgtcaaggg tcctgtcccg gctgcccctg cccgccggcg cctccagctg cctcggctgc gtgtacgaga agtggccgaa gaggctcagg cagcccggct ggccgccgcc gctcctcccc ccaggaaagc caaggtggag gctgaggtgg ctgcaggagc tcgtttcaca gcccctcagg tggagctggt tgggccgcgg ctgccagggg cggaggtggg tgtcccccag gtctcagccc ccaaggctgc cccctcagca gaggcagctg gtggctttgc cctccacctg ccaacccttg ggctcggagc cccggctccg cctgctgtgg aggccccagc cgtgggaatc caggtccccc aggtggagct gcctgccttg ccctcactgc ccactctgcc cacacttccc tgcctagaga cccgggaagg ggctgtgtcg gtagtggtgc ccaccctgga tgtggcagca ccgactgtgg gggtggacct ggccttgccg ggtgcagagg tggaggcccg gggagaggca cctgaggtgg ccctgaagat gccccgcctt agttttcccc gatttggggc tcgagcaaag gaagttgctg aggccaaggt agccaaggtc agccctgagg ccagggtgaa aggtcccaga cttcgaatgc ccacctttgg gctttccctc ttggagcccc ggcccgctgc tcctgaagtt gtagagagca agctgaagct gcccaccatc aagatgccct cccttggcat cggagtgtca gggcccgagg tcaaggtgcc caagggacct gaagtgaagc tccccaaggc tcctgaggtc aagcttccaa aagtgcccga ggcagccctt ccagaggttc gactcccaga ggtggagctc cccaaggtgt cagagatgaa actcccaaag gtgccagaga tggctgtgcc ggaggtgcgg cttccagagg tagagctgcc caaagtgtca gagatgaaac tcccaaaggt gccagagatg gctgtgccgg aggtgcggct tccagaggta cagctgctga aagtgtcgga gatgaaactc ccaaaggtgc cagagatggc tgtgccggag gtgcggcttc cagaggtaca gctgccgaaa gtgtcagaga tgaaactccc agaggtgtca gaggtggctg tgccagaggt gcggcttcca gaggtgcagc tgccgaaagt gccagagatg aaagtccctg agatgaagct tccaaaggtg cctgagatga aacttcctga gatgaaactc cctgaagtgc aactcccgaa ggtgcccgag atggccgtgc ccgatgtgca cctcccagaa gtgcagcttc caaaagtccc agagatgaag ctccctgaga tgaaactccc tgaggtgaaa ctcccgaagg tgcccgagat ggctgtgccc gatgtgcacc tcccggaagt gcagctcccg aaagtcccag agatgaaact ccctaaaatg cctgagatgg ctgtgccaga ggttcgactc cccgaggtgc agctgccaaa agtctcagag atgaaactcc ccaaggtgcc tgaaatggcc gtgcccgatg tgcacctccc agaggtgcag ctgcccaaag tctgtgaaat gaaagtccct gacatgaagc tcccagagat aaaactcccc aaggtgcctg agatggctgt gcccgatgtg cacctccccg aggtgcagct gccgaaagtg tcagagattc ggctgccgga aatgcaagtg ccgaaggttc ccgacgtgca tcttccgaag gcaccagagg tgaagctgcc cagggctccg gaggtgcagc taaaggccac caaggcagaa caggcagaag ggatggaatt tggcttcaag atgcccaaga tgaccatgcc caagctaggg agggcagagt ccccatcacg tggcaagcca ggcgaggcgg gtgctgaggt ctcagggaag ctggtaacac ttccctgtct gcagccagag gtggatggtg aggctcatgt gggtgtcccc tctctcactc tgccttcagt ggagctagac ctgccaggag cacttggcct gcaggggcag gtcccagccg ctaaaatggg caagggagag cgggtggagg gccctgaggt ggcagcaggg gtcagggaag tgggcttccg agtgccctct gttgaaattg tcaccccaca gctgcccgcc gtggaaattg aggaagggcg gctggagatg atagagacaa aagtcaagcc ctcttccaag ttctccttac ctaagtttgg actctcgggg ccaaaggtgg ctaaggcaga ggctgagggg gctgggcgag ctaccaagct gaaggtatcc aaatttgcca tctcactccc caaggctcgg gtgggggctg aggctgaggc caaaggggct ggggaggcag gcctgctgcc tgccctcgat ctgtccatcc cacagctcag cctggatgcc cacctgccct caggcaaggt agaggtggca ggggccgacc tcaagttcaa ggggcccagg tttgctctcc ccaagtttgg ggtcagaggc cgggacactg aggcagcaga actagtgcca ggggtggctg agttggaggg caagggctgg ggctgggatg ggagggtgaa gatgcccaag ctgaagatgc cttcctttgg gctggctcga gggaaggaag cagaagttca aggtgatcgt gccagcccgg gggaaaaggc tgagtccacc gctgtgcagc ttaagatccc cgaggtggag ctggtcacgc tgggcgccca ggaggaaggg agggcagagg gggctgtggc cgtcagtgga atgcagctgt caggcctgaa ggtgtccaca gccaggcagg tggtcactga gggccatgac gcggggctga ggatgcctcc gctgggcatc tccctgccac aggtggagct gaccggcttt ggggaggcag gtaccccagg gcagcaggct cagagtacag tcccttcagc agagggcaca gcaggctaca gggttcaggt gccccaggtg accctgtctc tgcctggagc ccaggttgca ggtggtgagc tgctggtggg tgagggtgtc tttaagatgc ccaccgtgac agtgccccag cttgagctgg acgtggggct aagccgagag gcacaggcgg gcgaggcggc cacaggcgag ggtgggctga ggctgaagtt gcccacactg ggggccagag ctagggtggg gggcgagggt gctgaggagc agcccccagg ggccgagcgt accttctgcc tctcactgcc cgacgtggag ctctcgccat ccgggggcaa ccatgccgag taccaggtgg cagaggggga gggagaggcc ggacacaagc tcaaggtacg gctgccccgg tttggcctgg tgcgggccaa ggagggggcc gaggagggtg agaaggccaa gagccccaaa ctcaggctgc cccgagtggg cttcagccaa agtgagatgg tcactgggga agggtccccc agccccgagg aggaggagga ggaggaggaa gagggcagtg gggaaggggc ctcgggtcgc cggggccggg tccgggtccg cttgccacgt gtaggcctgg cggccccttc taaagcctct cgggggcagg agggcgatgc agcccccaag tcccccgtca gagagaagtc acccaagttc cgcttcccca gggtgtccct aagccccaag gcccggagtg ggagtgggga ccaggaagag ggtggattgc gggtgcggct gcccagcgtg gggttttcag agacaggggc tccaggcccg gccaggatgg agggggctca ggctgcggct Protein function: Scaffolding protein that functions as part of a dystroglycan complex in Schwann cells, and as part of EZR and AHNAK-containing complexes in eye lens fiber cells. Required for the maintenance of the peripheral myelin sheath that is essential for normal transmission of nerve impulses and normal perception of sensory stimuli. Required for normal transport of MBP mRNA from the perinuclear to the paranodal regions. Required for normal remyelination after nerve injury. Required for normal elongation of Schwann cells and normal length of the internodes between the nodes of Ranvier. The demyelinated nodes of Ranvier permit saltatory transmission of nerve impulses, shorter internodes cause slower transmission of nerve impulses. Required for the formation of appositions between the abaxonal surface of the myelin sheath and the Schwann cell plasma membrane, the Schwann cell cytoplasm is restricted to regions between these appositions. Required for the formation of Cajal bands and of Schmidt-Lanterman incisures that correspond to short, cytoplasm-filled regions on myelinated nerves. Recruits DRP2 to the Schwann cell plasma membrane. Required for normal protein composition of the eye lens fiber cell plasma membrane and normal eye lens fiber cell morphology. [The UniProt Consortium]