PRUNE (Vector pUC, Accession No. BC014886)

Length: 816 Sequence: ATGGACCTTA AAATTGGAAA GGCAACCCCA AAGGACAGCA AATATGTGGA GAAACTAGAG GCCCTTTTCC CAGACCTACC CAAGAGAAAT GATATATTTG ATTCCCTACA AAAGGCAAAG TTTGATGTAT CAGGACTGAC CACTGAGCAG ATGCTGAGAA AGGACCAGAA GACTATCTAT AGACAAGGCG TCAAGGTGGC CATTAGTGCA ATATATATGG ATTTGGAGGC CTTTCTGCAG AGGTCTAACC TCCTTGCAGA TCTCCATGCT TTCTGCCAGG CTCACAGCTA TGATGTCCTG GTTGCCATGA CTATCTTTTT CAACACTCAC AATGAGCCAG TGCGGCAGTT GGCTATTTTC TGTCCCCATG TGGCACTCCA AACAACGATC TGTGAAGTCC TGGAACGCTC CCACTCTCCA CCCCTGAAGC TGACCCCTGC CTCAAGTACC CACCCTAACC TCCATGCCTA TCTTCAAGGC AACACCCAGG TCTCTCGAAA GAAACTTCTG CCCCTGCTCC AGGAAGCCCT GTCAGCATAT TTTGACTCCA TGAAGATCCC TTCAGGACAG CCTGAGACAG CAGATGTGTC CAGGGAGCAA GTGGACAAGG AATTGGACAG GGCAAGTAAC TCCCTGATTT CTGGACTGAG TCAAGATGAG GAGGACCCTC CGCTGCCCCC GACGCCCATG AACAGCTTGG TGGATGAGTG CCCTCTAGAT CAGGGGCTGC CTAAACTCTC TGCTGAGGCC GTCTTCGAGA AGTGCAGTCA GATCTCACTG TCACAGTCTA CCACAGCCTC CCTGTCCAAG Protein function: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956). [The UniProt Consortium]