PQBP1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 798 Sequence: atgccgctgc ccgttgcgct gcagacccgc ttggccaaga gaggcatcct caaacatctg gagcctgaac cagaggaaga gatcattgcc gaggactatg acgatgatcc tgtggactac gaggccacca ggttggaggg cctaccacca agctggtaca aggtgttcga cccttcctgc gggctccctt actactggaa tgcagacaca gaccttgtat cctggctctc cccacatgac cccaactccg tggttaccaa atcggccaag aagctcagaa gcagtaatgc agatgctgaa gaaaagttgg accggagcca tgacaagtcg gacaggggcc atgacaagtc ggaccgcagc catgagaaac tagacagggg ccacgacaag tcagaccggg gccacgacaa gtctgacagg gatcgagagc gtggctatga caaggtagac agagagagag agcgagacag ggaacgggat cgggaccgcg ggtatgacaa ggcagaccgg gaagagggca aagaacggcg ccaccatcgc cgggaggagc tggctcccta tcccaagagc aagaaggcag taagccgaaa ggatgaagag ttagacccca tggaccctag ctcatactca gacgcccccc ggggcacgtg gtcaacagga ctccccaagc ggaatgaggc caagactggc gctgacacca cagcagctgg gcccctcttc cagcagcggc cgtatccatc cccaggggct gtgctccggg ccaatgcaga ggcctcccga accaagcagc Protein function: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437). [The UniProt Consortium]