PPP6C (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 918 Sequence: atggcgccgc tagacctgga caagtatgtg gaaatagcgc ggctgtgcaa gtacctgcca gagaacgacc tgaagcggct atgtgactac gtttgtgacc tcctcttaga agagtcaaat gttcagccag tatcaacacc agtaacagtg tgtggagata tccatggaca gttttatgac ctttgtgaac tgttcagaac tggaggtcag gttcctgaca caaactacat atttatgggt gattttgtag acagaggtta ctatagtttg gagaccttca cttaccttct tgcattaaag gctaaatggc ctgatcgtat tacacttttg cgaggaaatc atgagagtag acagataaca caggtctatg gattttatga tgagtgccaa accaaatatg gaaatgctaa tgcctggaga tactgtacca aagtttttga catgctcaca gtagcagctt taatagatga gcagattttg tgtgtccatg gtggtttatc tcctgatatc aaaacactgg atcaaattcg aaccatcgaa cggaatcagg aaattcctca taaaggagca ttttgtgatc tggtttggtc agatcctgaa gatgtggata cctgggctat cagtccccga ggagcaggtt ggctttttgg agcaaaggtc acaaatgagt ttgttcatat caacaactta aaactcatct gcagagcaca tcaactagtg cacgaaggct ataaatttat gtttgatgag aagctggtga cagtatggtc tgctcctaat tactgctatc gttgtggaaa tattgcttcg atcatggtct tcaaagatgt aaatacaaga gaaccaaagt tattccgggc agttccagat tcagaacgtg ttattcctcc cagaacgaca acgccatatt Protein function: Catalytic subunit of protein phosphatase 6 (PP6) (PubMed:17079228, PubMed:29053956). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation (PubMed:10227379). N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1 (PubMed:17568194). During mitosis, regulates spindle positioning (PubMed:27335426). Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7 (PubMed:17079228). Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG- I/DDX58-mediated signaling activation (PubMed:29053956). [The UniProt Consortium]