PPP2R2D (Vector pUC, Accession No. BC047379)

Length: 1362 Sequence: atggcaggag ccggaggcgg cggctgcccc gcgggcggca acgacttcca gtggtgcttc tcgcaggtca agggggccat cgacgaggac gtggccgaag cggacatcat ttccaccgtt gagtttaatt actctggaga tcttcttgca acaggagaca agggcggcag agttgttatt tttcagcgtg aacaagagaa taaaagccgc cctcattcta ggggagaata taatgtttac agcacctttc aaagtcatga accggagttt gactatttga aaagtctaga aattgaggaa aaaattaata aaattaggtg gttaccacaa cagaatgctg ctcattttct actgtctaca aatgataaaa ctataaaatt atggaaaata agtgaacggg ataaaagagc agaaggttat aacctgaaag acgaagatgg aagacttcga gacccattta ggatcacggc gctacgggtc ccaatattga agcccatgga tcttatggta gaagcgagtc cacggcgaat ttttgcaaat gctcacacat atcatataaa ttccatttca gtaaatagtg atcatgaaac atatctttct gcagatgacc tgagaattaa tttatggcac ttagaaatca cagatagaag ctttaacatc gtggacatca agcctgctaa catggaggag ctgaccgaag tcatcactgc agccgagttc cacccgcacc agtgcaacgt gttcgtctac agcagtagca aagggaccat ccgcctgtgt gacatgcgct cctcggccct gtgcgacaga cactccaagt tttttgaaga gcctgaagat cccagcagta ggtccttctt ctcagaaata atttcatcca tatccgatgt aaaattcagt catagtgggc ggtacatgat gaccagagac tacctgtcgg tgaaggtgtg ggacctcaac atggagagca ggccggtgga gacccaccag gtccacgagt acctgcgcag caagctctgc tctctctatg agaacgactg catctttgac aagtttgagt gttgctggaa cggttcggat agcgccatca tgaccgggtc ctataacaac ttcttcagga tgtttgatag agacacgcgg agggatgtga ccctggaggc ctcgagagag agcagcaaac cgcgcgccag cctcaaaccc cggaaggtgt gtacgggggg taagcggagg aaagacgaga tcagtgtgga cagtctggac ttcaacaaga agatcctgca cacagcctgg caccccgtgg acaatgtcat tgccgtggct gccaccaata acttgtacat attccaggac aaaatcaact Protein function: B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment. [The UniProt Consortium]