PPP1R16B (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 1704 Sequence: ATGGCCAGTC ACGTGGACCT GCTGACGGAG CTGCAGCTGC TGGAGAAGGT GCCCACGCTG GAGCGGCTGC GGGCTGCCCA GAAGCGCCGG GCCCAGCAGC TGAAGAAATG GGCACAGTAC GAGCAGGACT TGCAGCACCG CAAGCGAAAG CATGAGCGGA AGCGCAGCAC GGGCGGCCGC CGCAAGAAAG TGTCCTTCGA GGCCAGCGTG GCCCTGCTGG AGGCCTCGCT GAGGAACGAC GCCGAGGAAG TACGCTACTT CCTGAAGAAT AAGGTCAGCC CTGATTTGTG CAATGAGGAC GGACTCACAG CCCTACACCA GTGCTGCATC GACAACTTTG AGGAAATTGT GAAGCTGCTC CTCTCCCATG GTGCCAATGT GAACGCCAAG GACAACGAGC TGTGGACACC TCTCCATGCT GCAGCCACCT GCGGCCACAT CAACCTGGTG AAGATCCTCG TTCAGTATGG GGCCGACTTG CTTGCTGTCA ACTCGGATGG GAACATGCCA TATGACCTCT GCGAGGATGA ACCCACCCTG GATGTCATCG AGACCTGCAT GGCATACCAG GGCATCACCC AAGAGAAAAT CAACGAGATG CGGGTGGCTC CTGAGCAGCA GATGATTGCG GACATCCACT GCATGATCGC AGCGGGCCAG GACCTGGACT GGATAGATGC CCAGGGTGCC ACACTGCTGC ACATAGCTGG AGCCAATGGA TACCTGCGGG CAGCTGAGCT CCTCCTGGAT CATGGAGTGC GTGTGGATGT GAAGGACTGG GATGGCTGGG AGCCCCTGCA TGCAGCTGCC TTCTGGGGAC AGATGCAGAT GGCAGAGCTA TTGGTGTCCC ATGGAGCTAG TCTCAGTGCA AGGACATCCA TGGATGAGAT GCCAATAGAC CTGTGCGAGG AGGAAGAGTT CAAGGTCCTG CTGCTGGAGC TAAAACACAA GCATGATGTG ATCATGAAGT CACAGCTGAG GCACAAGTCA TCCTTGAGCC GGAGGACCTC CAGCGCAGGC AGCCGTGGGA AGGTGGTGCG GCGAGCCAGC CTGTCGGACA GGACCAACCT GTATAGGAAG GAGTATGAGG GAGAGGCCAT CCTGTGGCAG CGGAGTGCAG CTGAGGATCA GCGGACCTCC ACCTACAACG GGGACATCAG GGAGACCAGG ACAGACCAAG AGAATAAGGA CCCTAACCCC AGGCTGGAGA AGCCCGTGCT ACTCTCCGAA TTTCCTACCA AGATCCCACG AGGTGAACTG GACATGCCTG TTGAGAATGG CCTCCGGGCT CCGGTCAGTG CCTACCAGTA TGCGCTGGCC AACGGGGATG TCTGGAAGGT GCATGAGGTG CCTGACTACA GCATGGCCTA TGGCAACCCT GGCGTGGCCG ACGCCACCCC GCCCTGGAGC AGCTACAAGG AACAGAGCCC TCAGACGCTT CTGGAGCTGA AGCGGCAGCG GGCTGCAGCC AAGCTGCTCA GCCACCCCTT CCTTAGCACA CACCTGGGCA GCAGCATGGC CAGGACGGGC GAGAGTAGCA GTGAAGGCAA GGCCCCCTTG ATCGGAGGCA GAACTTCACC GTACAGCAGC AATGGGACCT CGGTATATTA CACGGTCACC AGCGGAGATC CCCCACTCTT AAAGTTCAAG GCCCCCATAG AGGAGATGGA GGAGAAGGTG CATGGCTGTT GCCGTATCTC Protein function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity. Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934). [The UniProt Consortium]