PPHLN1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 777 Sequence: atggcttaca gaagagacga aatgtggtct gagggacgat atgaatatga aagaattccg agagaacgag cacctcctcg aagtcatccc agtgatgaat ctggttatag atggacaaga gacgatcatt ctgcaagcag gcaacctgaa tacagggaca tgagagatgg ctttagaaga aaaagtttct actcttccca ttatgcgaga gagcggtctc cttataaaag ggacaatact tttttcagag aatcacctgt tggccgaaag gattctccac acagcagatc tggttccagt gtcagtagca gaagctactc tccagaaagg agcaaatcat actctttcca tcagtctcaa catagaaagt ccgtgcgtcc tggtgcctcc tacaaacggc agaatgaagg aaatcctgaa agagataaag agaggcctgt ccagtctttg aaaacatcaa gagatacttc accctcaagt ggttcagcag tttcttcatc aaaggtgtta gacaaaccca gtaggctaac tgaaaaggaa cttgctgagg ctgcaagcaa gtgggctgct gaaaagctag agaaatcaga tgaaagtaac ttgcctgaaa tttctgagta tgaggcggga tccacagcac cattgtttac tgaccagcca gaggaacctg agtcaaacac aacacatggg atagaattat ttgaagatag tcagctaacc actcgctcta aagcaatagc atcaaaaacc aaagagattg aacaggtgag Protein function: Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (PubMed:30487602). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (PubMed:12853457). [The UniProt Consortium]