PNPLA8 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2349 Sequence: atgtctatta atctgactgt agatatatat atttacctcc ttagtaatgc aagaagtgtt tgtgggaagc agagaagcaa gcaactgtat ttcttgttct cacctaagca ttactggagg ataagccaca tcagtctaca aagaggtttt catacaaaca taataagatg taaatggacc aaaagtgaag cacattcttg cagtaagcac tgttactctc caagcaacca tggtttacat attgggattt tgaaacttag cacttctgct cccaagggac ttacaaaagt gaacatttgt atgtcccgta ttaaaagtac tttgaactct gtttcaaagg ctgtttttgg caatcaaaat gaaatgattt cacgtttagc tcaatttaag ccaagttccc aaattttaag aaaagtatcg gatagtggct ggttaaaaca gaaaaacatc aaacaagcca tcaaatctct gaaaaaatat agtgacaaat cagcagaaaa gagtcctttt ccagaagaga aaagtcacat tatagacaaa gaagaagata taggtaaacg cagtcttttt cattacacaa gttctataac cacaaaattt ggagactcat tctacttttt atcaaatcat attaattcat atttcaaacg taaggaaaaa atgtctcaac aaaaggaaaa tgaacatttc cgggacaaat cagaacttga agataaaaag gtagaagagg ggaaattaag atctccagat cctggcatcc tggcttataa gccaggctca gaatctgtac atacggtgga caagcctaca agtccttctg cgatacctga tgttcttcaa gtttcaacta aacaaagtat tgctaacttt ctttctcgtc ccacggaagg tgtacaagct ttagtaggtg gttatattgg tggacttgtc cccaaattaa agtatgattc aaagagtcag tcagaagaac aggaagagcc tgctaaaact gatcaggctg tcagcaaaga cagaaatgca gaggagaaaa agcgtttatc tcttcagcga gaaaagatta tcgcaagggt gagtattgat aacaggaccc gggcattagt tcaggcatta agaagaacaa ctgacccaaa gctctgcatt actagggttg aagaactgac ttttcatctt ctagaatttc ctgaaggaaa aggagtggct gtcaaggaaa gaattattcc atatttatta cgactgagac aaattaagga tgaaactctt caggctgcag ttagagaaat tttggcccta attggctatg tggatccagt gaaagggaga ggaatccgaa ttctctcaat tgatggtgga ggaacaaggg gcgtggttgc tctccagacc ctacgaaaat tagttgaact tactcagaag ccagttcatc agctctttga ttacatttgt ggtgtaagca caggtgccat attagctttc atgttggggt tgtttcatat gcccttggat gaatgtgagg aactttatcg aaaattagga tcagatgtat tttcacaaaa tgtcattgtt ggaacagtaa aaatgagttg gagccatgca ttttatgaca gtcaaacatg ggaaaacatt cttaaggata ggatgggatc tgcactgatg attgaaacag caagaaaccc cacatgtcct aaggtagctg ctgtaagtac catagtaaat agagggataa cacccaaagc ttttgtgttc agaaactatg gtcattttcc tggaatcaac tctcattatt tgggaggctg tcagtataaa atgtggcagg ccattagagc ctcatctgct gctccaggct actttgcaga atatgcattg ggaaatgatc ttcatcaaga tggaggtttg cttctgaata acccttcggc attagctatg catgagtgta aatgtctttg gccagatgtg ccgttagagt gcatagtatc cctgggcact ggacgttatg agagtgatgt gagaaacacg gtaacataca caagcttgaa aactaaactt tctaatgtta tcaacagtgc tacagataca gaagaagtcc atataatgct tgatggcctg ttacctcctg acacctattt tagattcaat cctgtaatgt gtgaaaacat acctctagat gaaagtcgaa atgaaaagct ggatcagctg cagttggaag ggttgaaata catagaaaga aatgaacaaa aaatgaaaaa agttgcaaaa atattaagtc aagaaaaaac aactctgcag aaaattaatg attggataaa attaaaaact gatatgtatg aaggacttcc attcttttca Protein function: Calcium-independent phospholipase A2, which promotes cellular membrane hydrolysis and prostaglandin production (PubMed:10744668, PubMed:15695510). Catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, phosphytidylserine and to a lower extent phosphatidylcholine (PubMed:10744668). Cleaves membrane phospholipids (PubMed:15695510). Participates in the generation of lipid second messengers through the mobilization of arachidonic acid in response to cellular stimuli. Synthesizes 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling (PubMed:15908428). Participates in the lipid plasticity of myocardium, plays a role in the generation of signaling metabolites and has a prominent effect on the modulaton of energy storage and utilization (PubMed:17213206). Essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition. [The UniProt Consortium]