PNLDC1 (Vector pUC, Accession No. BC112246)

Length: 1563 Sequence: ATGTTCTGCA CCCGAGGACT GCTATTTTTT GCCTTCCTGG CAGGTCTGGA CATAGAGTTC ACGGGCCTTC GTTCTAACCT GTCTGGGCCC CAGCAGATCA GTCTTTTTGA TTTGCCATCG GAGTGGTATC TAAAGACCCG TCAGAGTGTT CAGCAATTTA CAGTCTGTCA GATTGGATTG TCTGTGTTTT CCGCTATTGA AGGAGAGGCA AACAAGTATA TAGCCCATTC GTGTAACTTC TATCTCTTCC CTACAACGTT TGGGATTTTG GACTCAGAAT TCTCCTTCCA GGCTTCCAGT GTTCAGTTTT TGAATCAGTA TGGCTTCAAC TATAACAAGT TTCTCAAAAA CGGAATCCCA TATATGAATG AAGAACAGGA GAAGAAAATT AGACACGATA TCCTGACTGG GAACTGGAGA GTTCGCAGCT CTCCGGATAA AGACCAAATC AAGGTGGTGA TTGACGAAGT GACGCGGTGG CTGGAGCTGG CCAAGGAAGG CGACTGGATG ACTCTTCCTG GGATCACTGG CTTCCAGGCC TTTGAGGTCC AACTGGTGCT GAGGCAGGCC CTCCCCAACA TCTGGACGGT GCTGAAAGAT GAGGGGGTGG TAGTGAAGAA AGTGAGTAAA CAACATCGTT GGTATCTTCA GAACACCTCT TGTGACCGAG AGAGCTGTTG GAAGGAAAAT ATTCTTCTCT CAGCAAGGGG TTTTTCTGTC TTTTTCCAAA TGCTGGTGAA AGCCCAGAAG CCCTTAGTGG GACATAATAT GATGATGGAC CTGCTGCACC TCCATGAGAA GTTCTTCAGA CCCCTCCCAG AAAGCTACGA TCAATTTAAG CAGAATATCC ACAGCCTATT TCCTGTTCTC ATTGATACCA AGAGTGTAAC AAAGGATATC TGGAAGGAGA TGAATTTCCC GAGGGTGTCG AATCTTTCGG AAGTCTATGA AGTCCTGAAC AGTGACTTGA ATCCCACCAA GAATTCTGGA CCAGAGATTG TTCACGCGAG CAGGTGTGAG AAATATGTTG AGACAAAGTG CCCCCACGAA GCCGCGTATG ATGCCTTCCT CTGTGGGTCA GTTCTTTTGA AAGTGGCACA CTTGCTTCTA CAGAAGATAT ACCACATCGA CCCCGTGCCC GAGTCATCCT TTCCTCAGTA CCTTGACGTG CTGGCTCCTT ACGTGAACCA AGTGAACCTC ATCCGAGCGG GGGTCCCAAA GATCAATTTT TCTGGTCCAG ATTATCCCAG TATCCGACCT CCCATCCTCA TCCTCAGCGT CAAAAGGTGG CCTGGGGTCA GCGAGCAGCA AGTCTACCAT AAGTTTCAGA ATCTCTGCAA GTTTGATGTC AGGCGACTCA CAAGAAGCCA GTTCTTACTC CTGACCAATA AGTTTAAGGA TGCGCGGAAC ATCCTGAAGG AGTACCGGGA CCACCCGACC CTGTGCATCT CCCTGTACCG CTACTGGAGG CACTCCCCAA ACGTCAACTG CCTGCTCCAA GTCTGTGGCA TAGTGACTGC CTGGGCCCTT CTCGCGTTCA TCCTTGGAAG ATCTGGTACC Protein function: 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails (PubMed:27515512). Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development (PubMed:27515512). May act as a regulator of multipotency in embryonic stem cells. [The UniProt Consortium]