PLSCR3 (Vector pUC, Accession No. BC011735)

Length: 888 Sequence: atggcaggct acttgccccc caaaggctac gccccttcgc ccccacctcc ctaccctgtc acccctgggt acccggagcc ggcgctacat cctgggcccg ggcaggcgcc agtgcccgcc caggtacctg ccccagctcc cggcttcgcc ctcttcccct cgcctggccc cgtggccttg gggtctgctg cccccttctt gccactgcca ggggtgcctt ctggcctcga attcctggtg cagattgatc agattttgat tcaccagaag gctgagcgag tggaaacgtt cctaggctgg gagacctgta atcggtatga actgcgctct ggggccgggc agcccctggg tcaggcggcc gaggagagca actgctgcgc ccgtctgtgc tgtggcgccc gccggccgct gcgtgtccgc ctggccgacc ccggggaccg tgagttgctg cgtttgctcc gcccgctgca ctgtggctgc agctgctgcc cctgtggcct ccaggagatg gaagtacagg ctccaccagg caccaccatt ggccacgtgc tacagacctg gcatcccttc ctccccaagt tctccatcca ggatgccgat cgccagacag tcttgcgagt ggtggggccc tgctggacct gtggctgtgg cacagacacc aactttgagg tgaagactcg ggatgaatcc cgcagtgtgg gccgcatcag caagcagtgg gggggcctgg tccgagaagc cctcacagat gcagatgact ttggcctaca gttcccgctg gacctggatg tgagggtgaa ggctgtgctg ctgggagcca cattcctcat tgactacatg ttctttgaga agcgaggagg cgctgggccc tctgccatca Protein function: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:29337693, PubMed:31769662). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (PubMed:14573790, PubMed:17226776, PubMed:18358005, PubMed:12649167). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (PubMed:14573790, PubMed:17226776, PubMed:18358005). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (PubMed:18491232). Regulates cardiolipin de novo biosynthesis and its resynthesis (PubMed:16939411). [The UniProt Consortium]