PLEKHO1 (Vector pENTR223.1, Accession No. BC010149)

Length: 1230 Sequence: atgatgaaga agaacaattc cgccaagcgg ggacctcagg atggaaacca gcagcctgca ccgcccgaga aggtcggctg ggtccggaaa ttctgcggga aagggatttt cagggagatt tggaaaaacc gctatgtggt gctgaaaggg gaccagctct acatctctga gaaggaggta aaagatgaga aaaatattca agaggtattt gacctgagtg actatgagaa gtgtgaagag ctccggaagt ccaagagcag gagcaagaaa aatcatagca agtttactct tgcccactcc aaacagcccg gtaacacggc acccaacctg atcttcctgg cagtgagtcc agaagagaag gaatcgtgga tcaatgccct caactctgcc atcacccgag ccaagaaccg tatcttggat gaggtcaccg ttgaggagga cagctatctt gcccatccca ctcgagacag ggcaaaaatc cagcactccc gccgcccccc aacaagggga cacctaatgg ctgtggcttc cacctctacc tcggatggga tgctgacctt ggacttgatc caagaggaag acccttcccc tgaggaacca acctcttgtg ctgagagctt tcgggttgac ctggacaagt ctgtggccca gctggcaggg agccggcgga gagcggactc agaccgcatc cagccctccg cagaccgggc aagcagtctc tcccgacctt gggaaaaaac agacaaaggg gccacctaca ccccccaggc acccaagaag ttgacgccca cagagaaagg ccgctgcgcc tccctggagg agatcctatc tcagcgggat gctgcctctg cccgcaccct ccagctgcgg gctgaggaac ccccaacccc tgccctcccc aacccggggc agctgtcccg gatccaggac ctggtagcaa ggaaactgga ggagactcag gagcttctgg cagaggttca gggactggga gatgggaagc gaaaggccaa ggacccccct cggtctccgc cggattctga gtcagagcag ctgctgctgg agacggaacg gctgctggga gaggcatcat cgaattggag ccaggcaaag agggtgctgc aggaggtcag ggagctgaga gacctgtaca gacagatgga cctgcagacc ccggactccc acctcagaca gaccaccccg cacagtcagt accggaagag Protein function: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. [The UniProt Consortium]