PLEKHF1 (Vector pUC, Accession No. BC002744)

Length: 840 Sequence: atggtggacc acttggccaa cacggagatc aacagccagc gcatcgcggc agtggagagc tgcttcgggg cctcggggca gccgctggcg ctgccaggcc gagtgctgct gggcgagggc gtgctgacca aagagtgccg caagaaggcc aagccgcgca tcttcttcct ctttaacgac atcctggtgt atggcagcat cgtgctcaac aagcgcaagt accgcagcca gcacatcatc cccctggagg aggtcacact ggagctgttg ccggagacgc tgcaggccaa gaaccgctgg atgatcaaga cggccaagaa gtcctttgtg gtgtcggccg cctccgctac ggagcgccag gaatggatta gccacatcga ggagtgcgtg cggcggcaac tgagggccac gggccgcccg cccagcacgg agcacgcggc accctggatc cccgacaagg ccacggacat ctgcatgcgc tgcacgcaga cgcgcttctc tgccctcacg aggcgccacc actgccgcaa gtgcggcttc gtggtctgcg ctgagtgctc gcgccagcgc ttcctgctcc cgcgcctgtc ccccaagccc gtgcgcgtct gcagcctctg ctaccgcgaa ctggccgccc agcagcggca ggaggaggcg gaggagcagg gcgcggggtc cccagggcag ccagcccacc tggcccggcc catctgcgga gcgtccagtg gagatgacga tgactccgac gaggacaagg agggcagcag ggacggcgac tggcccagca gcgtggagtt ctacgcctcg ggggtggcct ggtctgcctt Protein function: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8. [The UniProt Consortium]