PLD3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1473 Sequence: atgaagccta aactgatgta ccaggagctg aaggtgcctg cagaggagcc cgccaatgag ctgcccatga atgagattga ggcgtggaag gctgcggaaa agaaagcccg ctgggtcctg ctggtcctca ttctggcggt tgtgggcttc ggagccctga tgactcagct gtttctatgg gaatacggcg acttgcatct ctttgggccc aaccagcgcc cagccccctg ctatgaccct tgcgaagcag tgctggtgga aagcattcct gagggcctgg acttccccaa tgcctccacg gggaaccctt ccaccagcca ggcctggctg ggcctgctcg ccggtgcgca cagcagcctg gacatcgcct ccttctactg gaccctcacc aacaatgaca cccacacgca ggagccctct gcccagcagg gtgaggaggt cctccggcag ctgcagaccc tggcaccaaa gggcgtgaac gtccgcatcg ctgtgagcaa gcccagcggg ccccagccac aggcggacct gcaggctctg ctgcagagcg gtgcccaggt ccgcatggtg gacatgcaga agctgaccca tggcgtcctg cataccaagt tctgggtggt ggaccagacc cacttctacc tgggcagtgc caacatggac tggcgttcac tgacccaggt caaggagctg ggcgtggtca tgtacaactg cagctgcctg gctcgagacc tgaccaagat ctttgaggcc tactggttcc tgggccaggc aggcagctcc atcccatcaa cttggccccg gttctatgac acccgctaca accaagagac accaatggag atctgcctca atggaacccc tgctctggcc tacctggcga gtgcgccccc acccctgtgt ccaagtggcc gcactccaga cctgaaggct ctactcaacg tggtggacaa tgcccggagt ttcatctacg tcgctgtcat gaactacctg cccactctgg agttctccca ccctcacagg ttctggcctg ccattgacga tgggctgcgg cgggccacct acgagcgtgg cgtcaaggtg cgcctgctca tcagctgctg gggacactcg gagccatcca tgcgggcctt cctgctctct ctggctgccc tgcgtgacaa ccatacccac tctgacatcc aggtgaaact ctttgtggtc cccgcggatg aggcccaggc tcgaatccca tatgcccgtg tcaaccacaa caagtacatg gtgactgaac gcgccaccta catcggaacc tccaactggt ctggcaacta cttcacggag acggcgggca cctcgctgct ggtgacgcag aatgggaggg gcggcctgcg gagccagctg gaggccattt tcctgaggga ctgggactcc ccttacagcc atgaccttga cacctcagct gacagcgtgg gcaacgcctg ccgcctgctc Protein function: 5'->3' DNA exonuclease which digests single-stranded DNA (ssDNA) (PubMed:30312375). Regulates inflammatory cytokine responses via the degradation of nucleic acids, by reducing the concentration of ssDNA able to stimulate TLR9, a nucleotide-sensing receptor in collaboration with PLD4. May be important in myotube formation (PubMed:22428023). Plays a role in lysosomal homeostasis (PubMed:28128235). Involved in the regulation of endosomal protein sorting (PubMed:29368044). [The UniProt Consortium]