PLCZ1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1248 Sequence: ATGGAAATGA GATGGTTTTT GTCAAAGATT CAGGATGACT TCAGAGGTGG AAAAATTAAC CTAGAAAAAA CTCAGAGGTT ACTTGAAAAA TTAGATATTC GGTGCAGTTA TATTCATGTG AAACAGATTT TTAAGACATC TGACTACCCA GTGGTGCTCT CTTTAGAAAA TCACTGCTCC ACTGCCCAAC AAGAAGTAAT GGCAGACAAT TTGCAGGCTA CTTTTGGAGA GTCCTTGCTT TCTGATATGC TTGATGATTT TCCTGATACT CTACCATCAC CAGAGGCACT AAAATTCAAA ATATTAGTTA AAAATAAGAA AATAGGAACC TTAAAGGAAA CCCATGAAAG AAAAGGTTCT GATAAGCGTG GAGACAATCA AGACAAGGAA ACAGGGGTAA AAAAGTTACC TGGAGTAATG CTTTTCAAGA AAAAGAAGAC CAGGAAGCTA AAAATTGCTC TGGCCTTATC TGATCTTGTC ATTTATACGA AAGCTGAGAA ATTCAAAAGC TTTCAACATT CAAGATTATA TCAGCAATTT AATGAAAATA ATTCTATTGG GGAGACACAA GCCCGAAAAC TTTCAAAATT GCGAGTCCAT GAGTTTATTT TTCACACCAG GAAGTTCATT ACCAGAATAT ATCCCAAAGC AACAAGAGCA GACTCTTCTA ATTTTAATCC CCAAGAATTT TGGAATATAG GTTGTCAAAT GGTGGCTTTA AATTTCCAGA CCCCTGGTCT GCCCATGGAT CTGCAAAATG GGAAATTTTT GGATAATGGT GGTTCTGGAT ATATTTTGAA ACCACATTTC TTAAGAGAGA GTAAATCATA CTTTAACCCA AGTAACATAA AAGAGGGTAT GCCAATTACA CTTACAATAA GGCTCATCAG TGGTATCCAG TTGCCTCTTA CTCATTCATC ATCTAACAAA GGTGATTCAT TAGTAATTAT AGAAGTTTTT GGTGTTCCAA ATGATCAAAT GAAGCAGCAG ACTCGTGTAA TTAAAAAAAA TGCTTTTAGT CCAAGATGGA ATGAAACATT CACATTTATT ATTCATGTCC CAGAATTGGC ATTGATACGT TTTGTTGTTG AAGGTCAAGG TTTAATAGCA GGAAATGAAT TTCTTGGGCA ATATACTTTG CCACTTCTAT GCATGAACAA AGGTTATCGT CGTATTCCTC TGTTTTCCAG AATGGGTGAG AGCCTTGAGC CTGCTTCACT GTTTGTTTAT GTTTGGTACG Protein function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. [The UniProt Consortium]