PLA2G15 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 819 Sequence: atggtggaga gccttgtggg ctggggctac acacggggtg aggatgtccg aggggctccc tatgactggc gccgagcccc aaatgaaaac gggccctact tcctggccct ccgcgagatg atcgaggaga tgtaccagct gtatgggggc cctgtggtgc tggttgccca cagtatgggc aacatgtaca cgctctactt tctgcagcgg cagccgcagg cctggaagga caagtatatc cgggccttcg tgtcactggg tgcgccctgg gggggcgtgg ccaagaccct gcgcgtcctg gcttcaggag acaacaaccg gatcccagtc atcgggcccc tgaagatccg ggagcagcag cggtcagctg tctccaccag ctggctgctg ccctacaact acacatggtc acctgagaag gtgttcgtgc agacacccac aatcaactac acactgcggg actaccgcaa gttcttccag gacatcggct ttgaagatgg ctggctcatg cggcaggaca cagaagggct ggtggaagcc acgatgccac ctggcgtgca gctgcactgc ctctatggta ctggcgtccc cacaccagac tccttctact atgagagctt ccctgaccgt gaccctaaaa tctgctttgg tgacggcgat ggtactgtga acttgaagag tgccctgcag tgccaggcct ggcagagccg ccaggagcac caagtgttgc tgcaggagct gccaggcagc gagcacatcg agatgctggc caacgccacc accctggcct atctgaaacg tgtgctcctt Protein function: Has dual calcium-independent phospholipase and O- acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:29724779, PubMed:25727495). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:29724779, PubMed:25727495). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:29724779). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines. Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:29724779). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:30830753). Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance. At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (PubMed:10092508). [The UniProt Consortium]