PIP5K1B (Vector pENTR223.1, Accession No. BC030587)

Length: 1650 Sequence: atgtcttctg ctgctgaaaa tggagaggca gcacctggaa aacaaaatga agaaaaaacc tataaaaaga cacaagtgaa aaaccaaatc ctgtctcgtt tacccaagat tccgtgtaca ttcattcaag catggaccaa cacagagatg attacgttgc tagcctgtta ttacttcaga tcagtttcaa ctgcatcatc tgctattaaa ggtgctattc agctgggaat aggatacaca gtgggtaatc tcacttccaa gccagaacga gatgttctta tgcaagactt ttatgtggtg gaaagtgtgt tcctacccag cgaagggagc aatctgaccc cagcacatca ctacccagac tttagattta agacatacgc tccattagca ttccgatatt tcagagaact ttttggtatc aagcctgatg attacttgta ttccatctgc agtgaacctc taatagaact gtctaaccct ggagccagtg gatccttgtt ttttgtgacc agtgatgatg aatttatcat caaaacagtt cagcacaaag aagctgagtt tcttcagaag ctactgccag gctattacat gaatttaaac cagaatccaa ggactctttt gccaaaattt tacggactgt attgtatgca atcaggaggc attaatatca ggattgtggt gatgaacaac gttttgccac gctccatgag aatgcacttt acatatgact tgaaaggctc aacgtataag cgaagagcat cccgtaaaga gagagagaaa tccaacccca catttaagga cttagatttc ctgcaagaca tgcacgaagg gttgtatttt gatacggaaa catacaacgc gcttatgaaa acacttcaga gagactgccg ggtgctagaa agcttcaaga tcatggatta tagccttctg ttgggaattc atttcctgga ccattccctc aaagagaaag aggaggagac cccacaaaat gtgcctgatg ctaagcggac tgggatgcag aaggttctct actcaacagc catggaatct atccagggtc cagggaaatc tggagatggg ataatcacag agaacccaga cacaatggga ggcattccag ctaaaagcca taggggagaa aaactacttt tatttacggg cattattgac attctgcaat catataggtt aatgaagaag ttagaacatt cctggaaagc tcttgtttat gatggggaca ctgtttctgt tcatagacca agcttttatg cagacagatt tcttaagttc atgaattcca gagttttcaa gaaaattcaa gctttgaagg cttcaccgtc taagaaacgg tgcaattcaa tcgccgccct aaaggccact tcacaggaga ttgtgtcctc aattagccag gaatggaagg atgagaagcg ggatttgctg actgaaggac aaagttttag cagccttgat gaagaagccc tgggatcccg acacaggcca gacctggtcc ctagcactcc atcactgttt gaagctgctt ccttggcaac cacaatttca tcttcttcct tatacgtcaa tgagcactat ccacacgaca ggcctacact ctattcaaac aggttcaaga tggcaacatc Protein function: Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion. [The UniProt Consortium]