PHLDA3 (Vector pUC, Accession No. BC014390)

Length: 384 Sequence: atgacggcgg cggcgacggc taccgtgctc aaggagggcg tgctggagaa gcgcagcggc gggctgctgc agctgtggaa gcggaagcgc tgcgtcctca ccgaacgcgg gctgcagctc ttcgaggcca agggcacggg cggccggccc aaggagctca gcttcgcccg catcaaggcc gtggagtgcg tggagagcac cgggcgccac atctacttca cgctggtgac cgaagggggc ggcgagatcg acttccgctg ccccctggaa gatcccggct ggaacgccca gatcacccta ggcctggtca agttcaagaa ccagcaggcc atccagacag tgcgggcccg gcagagcctc gggaccggga ccctcgtgtc Protein function: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. [The UniProt Consortium]