PHAX (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1185 Sequence: atggcgttgg aggtcggcga tatggaagat gggcagcttt ccgactcgga ttccgacatg acggtcgcac ccagcgacag gccgctgcaa ttgccaaaag tgctaggtgg cgacagtgct atgagggcct tccagaacac ggcaactgca tgtgcaccag tatcacatta tcgagctgtt gaaagtgtgg attcaagtga agaaagtttt tctgattcag atgatgatag ctgtctttgg aaacgcaaac gacagaaatg ttttaaccct cctcccaaac cagagccttt tcagtttggc cagagcagtc agaaaccacc tgttgctgga ggaaagaaga ttaacaacat atggggtgct gtgctgcagg aacagaatca agatgcagtg gccactgaac ttggtatctt gggaatggag ggcactattg acagaagcag acaatccgag acctacaatt atttgcttgc caagaaactt aggaaggaat ctcaagagca tacaaaagat ctagacaagg aactagatga atatatgcat ggtggcaaaa aaatgggatc aaaggaagag gaaaatgggc aaggtcatct caaaaggaaa cgacctgtca aagacaggct agggaacaga ccagaaatga actataaagg tcgatacgag atcacagcgg aagattctca agagaaagtg gctgatgaaa tttcattcag gttacaggaa ccaaagaaag acctgatagc ccgagtagtg aggattattg gtaacaaaaa ggcaattgaa cttctgatgg aaaccgctga agttgaacaa aatggtggtc tctttataat gaatggtagt cgaagaagaa caccaggtgg agtttttctg aatctcttga aaaacactcc tagtatcagc gaggaacaaa ttaaggacat tttctacatt gaaaaccaaa aggaatatga aaataaaaaa gctgctagga agaggagaac acaagtgttg gggaaaaaga tgaaacaagc tattaaaagt ctaaattttc aagaagatga tgatacatca cgagaaactt ttgcaagtga cacgaatgag gccttggcct ctcttgatga gtcacaggaa ggacatgcag aagccaagtt ggaggcagag gaagccattg aagttgatca ttctcatgat ttggacatct Protein function: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. [The UniProt Consortium]