PHACTR4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 1893 Sequence: atggtcctgg acagtgtgga agcaggagac acaacacctc ctaccaaaag gaagagcaag ttctcaggct ttggcaagat cttcaagccc tggaaatgga ggaaaaaaaa aagtagtgat aaatttaaag agacttcaga agttttagaa cggaaaatat ctatgcgaaa gccaagagaa gagctggtta agagaggggt tctgttggaa gaccctgagc aaggtggtga ggatccagga aagccaagcg atgccatgtt aaagaatggc cataccaccc ccatagggaa tgccagatca tctagtccag tccaagtaga ggaagagcca gtaagattag caagtcttag gaaagctatt ccagaagagg acctaaagaa acgactaggc tcaactggaa gccagcctaa ttctgaagca gagtctgttc ctgagaatgt acccaaacca cctttacttc ctcccaaaag acccttgtcc tcttctcatg aagcaagtga agggcaagca aaggatgcca cttcctctgg cggcacggca aggttcatca tctccacctc catcaccaca gcacccgctg ccaccactgc tgccacaagc cttgcaaaga ctgttaatct ctctgtcacc ccttccccag cacccaggac tctgcctgct gctcctgcca gcactaacac tactgctacc ccaagcctca ctcatatggt ccctgccaag cagcccccta tccctccccc taaaccagct cacagaaata gcaaccctgt cattgctgaa ctgtcccaag caataaacag tggtacattg ttatcaaaac cgtccccacc cttaccacct aagagaggca ttccatcaac ctcagtaccc accttggagt ctgctgctgc catcaccaca aaaacaccaa gtgatgaaag agagaagagc acgtgttcta tgggctcgga actactacca atgatctcac ctcgctctcc gtccccccca ctgcctactc atatacctcc agagcctcca cgcacccctc cattccctgc taagactttt caagttgtgc cagaaattga gtttccacca tccttagatc tacaccagga gattccccag caggaagatc agaaaaagga agtccccaag aggatactgg accagaactt tggggagccc catataccct ctaggctgcc tccactccca ctgcatattc gaatccagca ggccctcacc agcccacttc ccatgactcc tattctggag ggttctcaca gagctcattc gttgcttttt gaaaacagtg acagcttttc tgaggacagc agtacgctgg gtcggaccag gtctcttccc atcactattg aaatgctaaa agttccagac gatgaagaag aagaggagca aacctgtcca tccacattca gtgaagaaat gacacctacc tcagtcattc ctaaattacc acagtgtcta cgggaggaag aagagaagga gagcgactct gattcagaag gtcccattca gtaccgagat gaagaagatg aagatgaaag ctatcagagt gctctcgcca acaaagtgaa gaggaaagac acactggcaa tgaagttgaa ccacagaccc agtgaaccag agttgaacct gaattcttgg ccttgtaaaa gcaaggagga gtggaatgaa atacggcacc agattggaaa cacactgatc cggcgactga gtcaaagacc aacaccagaa gaactagaac aacgcaatat attgcaacaa tatagagtga aatttggcct taaaagtctc ctcactgaga aggtttgggc ttccttgggg ctatttgtga gcatgttcag tctgaccaat ccatcccctg ttctctcagc actacttggc Protein function: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway. [The UniProt Consortium]