PHACTR4 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 2109 Sequence: atggaagatc catttgagga agcagaccag cccactacag agccaggcat ggtcctggac agtgtggaag caggagacac aacacctcct accaaaagga agagcaagtt ctcaggcttt ggcaagatct tcaagccctg gaaatggagg aaaaaaaaaa gtagtgataa atttaaagag acttcagaag ttttagaacg gaaaatatct atgcgaaagc caagagaaga gctggttaaa agaggggttc tgttggaaga ccctgagcaa ggtggtgagg atccaggaaa gccaagcgat gccatgttaa agaatggcca taccaccccc atagggaatg ccagatcatc tagtccagtc caagtagagg aagagccagt aagattagca agtcttagga aagctattcc agaagaggac ctaaagaaac gactaggctc aactggaagc cagcctaatt ctgaagcaga gtctgttcct gagaatgtac ccaaaccacc tttacttcct cccaaaagac ccttgtcctc ttctcatgaa gcaagtgaag ggcaagcaaa ggatgccact tcctctggcg gcacggcaag gttcatcatc tccacctcca tcaccacagc acccgctgcc accactgctg ccacaagcct tgcaaagact gttaatctct ctgtcacccc ttccccagca cccaggactc tgcctgctgc tcctgccagc actaacacta ctgctacccc aagcctcact catatggtcc ctgccaagca gccccctatc cctcccccta aaccagctca cagaaatagc aaccctgtca ttgctgaact gtcccaagca ataaacagtg gtacattgtt atcaaaaccg tccccaccct taccacctaa gagaggcatt ccatcaacct cagtacccac cttggagtct gctgctgcca tcaccacaaa aacaccaagt gatgaaagag agaagagcac gtgttctatg ggctcggaac tactaccaat gatctcacct cgctctccgt cccccccact gcctactcat atacctccag agcctccacg cacccctcca ttccctgcta agacttttca agttgtgcca gaaattgagt ttccaccatc cttagatcta caccaggaga ttccccagca ggaagatcag aaaaaggaag tccccaagag gatactggac cagaactttg gggagcccca tataccctct aggctgcctc cactcccact gcatattcga atccagcagg ccctcaccag cccacttccc atgactccta ttctggaggg ttctcacaga gctcattcgt tgctttttga aaacagtgac agcttttctg aggacagcag tacgctgggt cggaccaggt ctcttcccat cactattgaa atgctaaaag ttccagacga tgaagaagaa gaggagcaaa cctgtccatc cacattcagt gaagaaatga cacctacctc agtcattcct aaattaccac agtgtctacg ggaggaagaa gagaaggaga gcgactctga ttcagaaggt cccattcagt accgagatga agaagatgaa gatgaaagct atcagagtgc tctcgccaac aaagtgaaga ggaaagacac actggcaatg aagttgaacc acagacccag tgaaccagag ttgaacctga attcttggcc ttgtaaaagc aaggaggagt ggaatgaaat acggcaccag attggaaaca cactgatccg gcgactgagt caaagaccaa caccagaaga actagaacaa cgcaatatat tgcaacctaa aaatgaagct gatcgtcagg cagaaaaacg agaaattaaa cgtcggctca ctagaaagct cagtcaaagg ccaactgtcg ctgaactcct tgccaggaag attctgaggt ttaatgaata tgtagaggta acagatgctc aagattatga ccggcgagcc gacaaacctt ggaccaaact gacccctgct gacaaggctg ccataagaaa agaattaaat gaatttaaaa gctccgagat ggaggttcat gaagagagca aacattttac acgctaccat Protein function: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway. [The UniProt Consortium]