PFKL (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 2484 Sequence: atgtgtaacc agggtagagg tcgagagtcc tctcgtgggg gtctccatgt tcaagggagc tgccgaggct tgagcaggag cccccagcag gaaactggct ttgccaaggc ccccgctggg acagactgtt tctttcactg cagtcctggg agccgagggc aaggggacag gaaagaggaa gtgacctcag agcctggtgg caccagcatc atgtccaggc tggggggcat gaacgctgct gtccgggctg tgacgcgcat gggcatttat gtgggtgcca aagtcttcct catctacgag ggctatgagg gcctcgtgga gggaggtgag aacatcaagc aggccaactg gctgagcgtc tccaacatca tccagctggg cggcactatc attggcagcg ctcgctgcaa ggcctttacc accagggagg ggcgccgggc agcggcctac aacctggtcc agcacggcat caccaacctg tgcgtcatcg gcggggatgg cagccttaca ggtgccaaca tcttccgcag cgagtggggc agcctgctgg aggagctggt ggcggaaggt aagatctcag agactacagc ccggacctac tcgcacctga acatcgcggg cctagtgggc tccatcgata acgacttctg cggcaccgac atgaccatcg gcacggactc ggccctccac cgcatcatgg aggtcatcga tgccatcacc accactgccc agagccacca gaggaccttc gtgctggaag tgatgggccg gcactgcggg tacctggcgc tggtatctgc actggcctca ggggccgact ggctgttcat ccccgaggct ccacccgagg acggctggga gaacttcatg tgtgagaggc tgggtgagac tcggagccgt gggtcccgac tgaacatcat catcatcgct gagggtgcca ttgaccgcaa cgggaagccc atctcgtcca gctacgtgaa ggacctggtg gttcagaggc tgggcttcga cacccgtgta actgtgctgg gccacgtgca gcggggaggg acgccctctg ccttcgaccg gatcctgagc agcaagatgg gcatggaggc ggtgatggcg ctgctggaag ccacgcctga cacgccggcc tgcgtggtca ccctctcggg gaaccagtca gtgcggctgc ccctcatgga gtgcgtgcag atgaccaagg aagtgcagaa agccatggat gacaagaggt ttgacgaggc cacccagctc cgtggtggga gcttcgagaa caactggaac atttacaagc tcctcgccca ccagaagccc cccaaggaga agtctaactt ctccctggcc atcctgaatg tgggggcccc ggcggctggc atgaatgcgg ccgtgcgctc ggcggtgcgg accggcatct cccatggaca cacagtatac gtggtgcacg atggcttcga aggcctagcc aagggtcagg tgcaagaagt aggctggcac gacgtggccg gctggttggg gcgtggtggc tccatgctgg ggaccaagag gaccctgccc aagggccagc tggagtccat tgtggagaac atccgcatct atggtattca cgccctgctg gtggtcggtg ggtttgaggc ctatgaaggg gtgctgcagc tggtggaggc tcgcgggcgc tacgaggagc tctgcatcgt catgtgtgtc atcccagcca ccatcagcaa caacgtccct ggcaccgact tcagcctggg ctccgacact gctgtaaatg ccgccatgga gagctgtgac cgcatcaaac agtctgcctc ggggaccaag cgccgtgtgt tcatcgtgga gaccatgggg ggttactgtg gctacctggc caccgtgact ggcattgctg tgggggccga cgccgcctac gtcttcgagg accctttcaa catccacgac ttaaaggtca acgtggagca catgacggag aagatgaaga cagacattca gaggggcctg gtgctgcgga acgagaagtg ccatgactac tacaccacgg agttcctgta caacctgtac tcatcagagg gcaagggcgt cttcgactgc aggaccaatg tcctgggcca cctgcagcag ggtggcgctc caaccccctt tgaccggaac tatgggacca agctgggggt gaaggccatg ctgtggttgt cggagaagct gcgcgaggtt taccgcaagg gacgggtgtt cgccaatgcc ccagactcgg cctgcgtgat cggcctgaag aagaaggcgg tggccttcag ccccgtcact gagctcaaga aagacactga tttcgagcac cgcatgccac gggagcagtg gtggctgagc ctgcggctca tgctgaagat gctggcacaa taccgcatca gtatggccgc ctacgtgtca ggggagctgg agcacgtgac ccgccgcacc ctgagcatgg acaagggctt Protein function: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway. [The UniProt Consortium]