PELO (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1158 Sequence: atgaagctcg tgaggaagaa catcgagaag gacaatgcgg gccaggtgac cctggtcccc gaggagcctg aggacatgtg gcacacttac aacctcgtgc aggtgggcga cagcctgcgc gcctccacca tccgcaaggt acagacagag tcctccacgg gcagcgtggg cagcaaccgg gtccgcacta ccctcactct ctgcgtggag gccatcgact tcgactctca agcctgccag ctgcgggtta aggggaccaa catccaagag aatgagtatg tcaagatggg ggcttaccac accatcgagc tggagcccaa ccgccagttc accctggcca agaagcagtg ggatagtgtg gtactggagc gcatcgagca ggcctgtgac ccagcctgga gcgctgatgt ggcggctgtg gtcatgcagg aaggcctcgc ccatatctgc ttagtcactc ccagcatgac cctcactcgg gccaaggtgg aggtgaacat ccctaggaaa aggaaaggca attgctctca gcatgaccgg gccttggagc ggttctatga acaggtggtc caggctatcc agcgccacat acactttgat gttgtaaagt gcatcctggt ggccagccca ggatttgtga gggagcagtt ctgcgactac atgtttcaac aagcagtgaa gaccgacaac aaactgctcc tggaaaaccg gtccaaattt cttcaggtac atgcctcctc cggacacaag tactccctga aagaggccct ttgtgaccct actgtggcta gccgcctttc agacactaaa gctgctgggg aagtcaaagc cttggatgac ttctataaaa tgttacagca tgaaccggat cgagctttct atggactcaa gcaggtggag aaggccaatg aagccatggc aattgacaca ttgctcatca gcgatgagct cttcaggcat caggatgtag ccacacggag ccggtatgtg aggctggtgg acagtgtgaa agagaatgca ggcaccgtta ggatattctc tagtcttcac gtttctgggg aacagctcag ccagttgact ggggtagctg ccattctccg cttccctgtt cccgaacttt ctgaccaaga gggtgattcc agttctgaag Protein function: Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132, PubMed:29861391). In the presence of ABCE1 and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132). Together with HBS1L and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs, this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132). As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy (PubMed:29861391). [The UniProt Consortium]