PCSK4 (Vector pUC, Accession No. BC036354)

Length: 729 Sequence: atgggcacgc gctccacact cgtggccata cgacccttgg acgtcagcac tgaaggctac aacaactggg tcttcatgtc cacccacttc tgggatgaga acccacaggg cgtgtggacc ctgggcctag agaacaaggg ctactatttc aacacgggga cgttgtaccg ctacacgctg ctgctctatg ggacggccga ggacatgaca gcgcggccta caggccccca ggtgaccagc agcgcgtgtg tgcagcggga cacagagggg ctgtgccagg cgtgtgacgg ccccgcctac atcctgggac agctctgcct ggcctactgc cccccgcggt tcttcaacca cacaaggctg gtgaccgctg ggcctgggca cacggcggcg cccgcgctga gggtctgctc cagctgccat gcctcctgct acacctgccg cggcggctcc ccgagggact gcacctcctg tcccccatcc tccacgctgg accagcagca gggctcctgc atgggaccca ccacccccga cagccgcccc cggcttagag ctgccgcctg tccccaccac cgctgcccag cctcggccat ggtgctgagc ctcctggccg tgaccctcgg aggccccgtc ctctgcggca tgtccatgga cctcccacta tacgcctggc tctcccgtgc cagggccacc cccaccaaac cccaggtctg gctgccagct Protein function: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida. Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries. [The UniProt Consortium]