PAPSS1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 1812 Sequence: atgcagagag caaccaatgt cacctaccaa gcccatcatg tcagcaggaa caagagaggt caggtggtgg ggaccagagg tggctttcgt ggttgcacag tttggctaac aggcttgtct ggagcgggaa agactactgt gagcatggcc ttggaggagt acctggtttg tcatggtatt ccatgctaca ctctggatgg tgacaatatt cgtcaaggtc tcaataaaaa tcttggcttt agtcctgaag acagagaaga gaatgttcga cgcatcgcag aagttgctaa actgtttgca gatgctggct tagtgtgcat cacaagtttc atatcacctt acactcagga tcgcaacaat gcaaggcaaa ttcatgaagg tgcaagttta ccgttttttg aagtatttgt tgatgctcct ctgcatgttt gtgaacagag ggatgtcaaa ggactctaca aaaaagcccg ggcaggagaa attaaaggtt tcactgggat cgattctgaa tatgaaaagc cagaggcccc tgagttggtg ctgaaaacag actcctgtga tgtaaatgac tgtgtccagc aagttgtgga acttctacag gaacgggata ttgtacctgt ggatgcatct tatgaagtaa aagaactata tgtgccagaa aataaacttc atttggcaaa aacagatgcg gaaacattac cagcactgaa aattaataaa gtggatatgc agtgggtgca ggttttggca gaaggttggg caaccccatt gaatggcttt atgagagaga gggagtactt gcagtgcctt cattttgatt gtcttctgga tggaggtgtc attaacttgt cagtacctat agttctgact gcgactcatg aagataaaga gaggctggac ggctgtacag catttgctct gatgtatgag ggccgccgtg tggccattct tcgcaatcca gagttttttg agcacaggaa agaggagcgc tgtgccagac agtggggaac gacatgcaag aaccacccct atattaagat ggtgatggaa caaggagatt ggctgattgg aggagatctt caagtcttgg atcgagttta ttggaatgat ggtcttgatc agtatcgtct tactcctact gagctaaagc agaaatttaa agatatgaat gctgatgctg tctttgcatt tcaactacgc aacccagtgc acaatggaca tgccctgtta atgcaggata cccataagca acttctagag aggggctacc ggcgccctgt cctcctcctc caccctctgg gtggctggac aaaggatgac gatgttcctt tgatgtggcg tatgaagcag catgctgcag tgttggagga aggagttctg aatcctgaga cgacagtggt ggccatcttc ccatctccca tgatgtatgc tggaccaact gaggtccagt ggcattgcag agcacggatg gttgcaggag ccaactttta cattgttgga cgagaccctg ctggcatgcc tcatccagaa acagggaagg atctttatga gccaagtcat ggtgccaaag tgctgacgat ggcccctggt ttaatcactt tggaaatagt tccctttcga gttgcagctt acaacaagaa aaagaagcgt atggactact atgactctga acaccatgaa gactttgaat ttatttcagg aacacgaatg cgcaaacttg ctcgagaagg ccagaaacca cctgaaggtt tcatggctcc caaggcttgg accgtgctga cagaatacta caaatccttg gagaaagctt Protein function: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate, APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:9576487, PubMed:9668121, PubMed:9648242, PubMed:14747722). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (PubMed:9576487). [The UniProt Consortium]