PAFAH1B3 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pU

Length: 696 Sequence: atgagtggag aggagaaccc agccagcaag cccacgccgg tgcaggacgt acagggcgac gggcgctgga tgtccctgca ccatcggttc gtggctgaca gcaaagataa ggaacccgaa gtcgtcttca tcggggactc cttggtccag ctcatgcacc agtgcgagat ctggcgcgag ctcttctctc ctctgcatgc acttaacttt ggcattggtg gtgacggcac acagcatgta ctgtggcggc tggagaatgg ggagctggaa cacatccggc ccaagattgt ggtggtctgg gtgggcacca acaaccacgg acacacagca gagcaggtga ctggtggcat caaggccatt gtgcaactgg tgaatgagcg acagccccag gcccgggttg tggtgctggg cctgcttccg cgaggccaac atcccaaccc acttcgggag aagaaccgac aggtgaacga gctggtacgg gcggcactgg ctggccaccc tcgggcccac ttcctagatg ccgaccctgg ctttgtgcac tcagatggca ccatcagcca tcatgacatg tatgattacc tgcatctgag ccgcctgggc tacacacctg tttgccgggc tctgcactcc ctgcttctgc gtctgctggc ccaagaccag ggccaaggtg ctcccctgct ggagcccgca Protein function: Alpha1 catalytic subunit of the cytosolic type I platelet- activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. [The UniProt Consortium]