OR51E2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 963 Sequence: atgagttcct gcaacttcac acatgccacc tttgtgctta ttggtatccc aggattagag aaagcccatt tctgggttgg cttccccctc ctttccatgt atgtagtggc aatgtttgga aactgcatcg tggtcttcat cgtaaggacg gaacgcagcc tgcacgctcc gatgtacctc tttctctgca tgcttgcagc cattgacctg gccttatcca catccaccat gcctaagatc cttgcccttt tctggtttga ttcccgagag attagctttg aggcctgtct tacccagatg ttctttattc atgccctctc agccattgaa tccaccatcc tgctggccat ggcctttgac cgttatgtgg ccatctgcca cccactgcgc catgctgcag tgctcaacaa tacagtaaca gcccagattg gcatcgtggc tgtggtccgc ggatccctct tttttttccc actgcctctg ctgatcaagc ggctggcctt ctgccactcc aatgtcctct cgcactccta ttgtgtccac caggatgtaa tgaagttggc ctatgcagac actttgccca atgtggtata tggtcttact gccattctgc tggtcatggg cgtggacgta atgttcatct ccttgtccta ttttctgata atacgaacgg ttctgcaact gccttccaag tcagagcggg ccaaggcctt tggaacctgt gtgtcacaca ttggtgtggt actcgccttc tatgtgccac ttattggcct ctcagttgta caccgctttg gaaacagcct tcatcccatt gtgcgtgttg tcatgggtga catctacctg ctgctgcctc ctgtcatcaa tcccatcatc tatggtgcca aaaccaaaca gatcagaaca cgggtgctgg ctatgttcaa gatcagctgt gacaaggact tgcaggctgt gggaggcaag Protein function: Olfactory receptor (PubMed:29249973, PubMed:27226631). Activated by the odorant, beta-ionone, a synthetic terpenoid (PubMed:29249973, PubMed:27226631, PubMed:19389702). The activity of this receptor is propably mediated by G-proteins leading to the elevation of intracellular Ca(2+), cAMP and activation of the protein kinases PKA and MAPK3/MAPK1 (PubMed:27226631, PubMed:29249973). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). Activated also by the short-chain fatty acids (SCFA) acetate and propionate. In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). May also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Activated by L-lactate in glomus cells. [The UniProt Consortium]