OPN5 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 1065 Sequence: atggcgttaa atcacactgc cctgcctcag gacgagcgcc tgccccatta ccttcgagat ggggatcctt ttgcttccaa actttcttgg gaagcggatt tagtggctgg cttttaccta acaataattg ggattctgtc cacatttgga aatggatatg tcctttacat gtcttctaga cgaaagaaga agctgagacc cgctgaaata atgactatca atttagcagt ctgtgatctg gggatttcag ttgtaggcaa gccgttcacc atcatctctt gcttttgtca ccgctgggtg tttggctgga tcggctgccg ctggtatgga tgggctggat ttttctttgg ctgtggaagc cttatcacca tgactgctgt cagcctggat cgatatttga aaatctgcta tttatcttat ggggtttggc tgaaaagaaa gcacgcctac atctgcctgg cagccatctg ggcctatgct tccttctgga ccaccatgcc cttggtaggt ctgggggact acgtacctga gcccttcgga acctcgtgca ccctggactg gtggctggcc caggcctcgg tagggggcca ggttttcatc ctgaacatcc tcttcttctg cctcttgctc ccaacggctg tgatcgtgtt ctcctacgta aagatcattg ccaaggttaa gtcctcttcc aaagaagtag ctcatttcga cagtcggatc catagcagcc atgtgctgga aatgaaactg acaaaggtag cgatgttgat ttgtgctgga ttcctgattg cctggattcc ttatgcagtg gtgtctgtgt ggtcagcttt tggaaggcca gactccattc ccatacagct ctctgtggtg ccaaccctac ttgcaaaatc tgcagcgatg tacaatccca tcatttacca agttattgat tacaaatttg cctgttgcca aactggtggt ttgaaagcaa ccaagaagaa gtctctggaa ggcttcaggc tgcacaccgt aaccacagtc aggaagtctt ctgctgtgct ggaaattcat gaagagtggg Protein function: G-protein coupled receptor which selectively activates G(i) type G proteins via ultraviolet A (UVA) light-mediated activation in the retina. Preferentially binds the chromophore 11-cis retinal and is a bistable protein that displays emission peaks at 380 nm (UVA light) and 470 nm (blue light) (PubMed:22043319). Required for the light-response in the inner plexiform layer, and contributes to the regulation of the light-response in the nerve fiber layer, via phosphorylated DAT/SLC6A3 dopamine uptake. Involved in local corneal and retinal circadian rhythm photoentrainment via modulation of the UVA light-induced phase-shift of the retina clock. Acts as a circadian photoreceptor in the outer ear, via modulation of circadian clock-gene expression in response to violet light during the light-to-dark transition phase and night phase of the circadian cycle. Required in the retina to negatively regulate hyaloid vessel regression during postnatal development via light-dependent OPN5-SLC32A1-DRD2-VEGFR2 signaling. Involved in the light-dependent regulation of retina and vitreous compartment dopamine levels. [The UniProt Consortium]